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    ADA adenosine deaminase [ Bos taurus (domestic cattle) ]

    Gene ID: 280712, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ADAprovided by VGNC
    Official Full Name
    adenosine deaminaseprovided by VGNC
    Primary source
    VGNC:VGNC:25600
    See related
    BGD:BT12388; Ensembl:ENSBTAG00000005280
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ADA in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (73028616..73052457, complement)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene cAMP-dependent protein kinase inhibitor gamma Neighboring gene small nucleolar RNA U2-30 Neighboring gene small nucleolar RNA U2-19 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC101902669 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected by Fasciola hepatica. DA Silva AS, et al. Parasitology, 2017 Apr. PMID 28103965
    2. Conformational change of adenosine deaminase during ligand-exchange in a crystal. Kinoshita T, et al. Biochem Biophys Res Commun, 2008 Aug 15. PMID 18549808
    3. The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency. Richard E, et al. J Exp Med, 2000 Nov 6. PMID 11067872, Free PMC Article
    4. Primary structure of bovine adenosine deaminase. Kelly MA, et al. J Pharm Biomed Anal, 1996 Aug. PMID 8877857
    5. Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus. da Silva AS, et al. Comp Immunol Microbiol Infect Dis, 2017 Apr. PMID 28504100

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
      Title: Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus.
    2. It was concluded that oxidative stress occurs in cattle experimentally infected by F. hepatica, mainly due to excessive ROS production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic adenosine deaminase (ADA) activity may contribute to the inflammatory process.
      Title: Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected by Fasciola hepatica.
    3. Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV.
      Title: Complex of dipeptidyl peptidase II with adenosine deaminase.
    4. This is the first report that an inhibitor molecule (EHNA) with a nucleoside framework binds to the open form of ADA and the first observation of conformational change of ADA in the crystalline state.
      Title: Conformational change of adenosine deaminase during ligand-exchange in a crystal.
    5. the transition-state structures of PfADA, HsADA, and bovine ADA (BtADA) solved using competitive kinetic isotope effects (KIE) and density functional calculations
      Title: Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases.
    6. Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase
      Title: Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hypoxanthine salvage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine deaminase
    Names
    adenosine aminohydrolase
    NP_776312.1
    XP_024856023.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173887.2 → NP_776312.1  adenosine deaminase

      Status: PROVISIONAL

      Source sequence(s)
      AF280603
      UniProtKB/Swiss-Prot
      P56658, Q9MYY1
      UniProtKB/TrEMBL
      A0AAA9SWQ3
      Related
      ENSBTAP00000006947.5, ENSBTAT00000006947.6
      Conserved Domains (1) summary
      TIGR01430
      Location:9 → 347
      aden_deam; adenosine deaminase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      73028616..73052457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025000255.2 → XP_024856023.2  adenosine deaminase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56658.3 GenPept UniProtKB/Swiss-Prot:P56658

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials