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    Map3k10 mitogen-activated protein kinase kinase kinase 10 [ Mus musculus (house mouse) ]

    Gene ID: 269881, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Map3k10provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 10provided by MGI
    Primary source
    MGI:MGI:1346879
    See related
    Ensembl:ENSMUSG00000040390 AllianceGenome:MGI:1346879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MST; Mlk2
    Summary
    Enables protein kinase activity and transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription and protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in brown fat; heart; ovary; renal vasculature; and testis. Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 23.3), frontal lobe adult (RPKM 19.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map3k10 in Genome Data Viewer
    Location:
    7 A3; 7 15.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27355800..27374059, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27656375..27674630, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28376489-28376676 Neighboring gene STARR-positive B cell enhancer ABC_E11346 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28377425-28377608 Neighboring gene thymoma viral proto-oncogene 2 Neighboring gene STARR-seq mESC enhancer starr_18379 Neighboring gene predicted gene, 38973 Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene STARR-seq mESC enhancer starr_18383 Neighboring gene zinc finger protein 607B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28474189-28474376 Neighboring gene STARR-seq mESC enhancer starr_18384 Neighboring gene PHD finger protein 5B, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of mixed lineage kinase 2 in germ cells of the testis. Phelan DR, et al. Mol Reprod Dev, 1999 Feb. PMID 9890743
    2. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Kant S, et al. Cell Rep, 2013 Aug 29. PMID 23954791, Free PMC Article
    3. Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Bisson N, et al. Cell Cycle, 2008 Apr 1. PMID 18414056
    4. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. Pedraza N, et al. J Biol Chem, 2009 Nov 20. PMID 19801649, Free PMC Article
    5. The corepressor activity of Alien is controlled by CREB-binding protein/p300. Eckey M, et al. FEBS J, 2013 Apr. PMID 23441852

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways
      Title: Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.
    2. There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
      Title: Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 10
    Names
    MKN28 derived nonreceptor_type
    MKN28 kinase
    mixed lineage kinase 2
    serine/threonine kinase
    NP_001277457.1
    XP_017177776.1
    XP_017177777.1
    XP_017177778.1
    XP_017177779.1
    XP_030098477.1
    XP_030098478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290528.1 → NP_001277457.1  mitogen-activated protein kinase kinase kinase 10

      See identical proteins and their annotated locations for NP_001277457.1

      Status: VALIDATED

      Source sequence(s)
      AK053830, BC078445
      Consensus CDS
      CCDS39850.2
      UniProtKB/Swiss-Prot
      Q66L42, Q80UW4
      UniProtKB/TrEMBL
      D3YXM8
      Related
      ENSMUSP00000037725.8, ENSMUST00000036453.14
      Conserved Domains (3) summary
      smart00219
      Location:98 → 357
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 360
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27355800..27374059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322288.3 → XP_017177777.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

      UniProtKB/TrEMBL
      D3YXM8
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 360
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017322289.3 → XP_017177778.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

      UniProtKB/TrEMBL
      D3YXM8
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 368
      PKc_like; Protein Kinases, catalytic domain

    3. XM_017322287.3 → XP_017177776.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

      UniProtKB/TrEMBL
      D3YXM8
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 368
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030242618.2 → XP_030098478.1  mitogen-activated protein kinase kinase kinase 10 isoform X6

      Conserved Domains (2) summary
      TIGR03319
      Location:4 → 88
      RNase_Y; ribonuclease Y
      PHA03247
      Location:252 → 550
      PHA03247; large tegument protein UL36; Provisional

    5. XM_030242617.2 → XP_030098477.1  mitogen-activated protein kinase kinase kinase 10 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:295 → 593
      PHA03247; large tegument protein UL36; Provisional
      pfam12072
      Location:72 → 132
      DUF3552; Domain of unknown function (DUF3552)

    6. XM_017322290.3 → XP_017177779.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:410 → 708
      PHA03247; large tegument protein UL36; Provisional
      pfam12072
      Location:187 → 247
      DUF3552; Domain of unknown function (DUF3552)
      cl21453
      Location:1 → 108
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004934110.1 RNA Sequence

    2. XR_004934109.1 RNA Sequence

    3. XR_001785564.3 RNA Sequence

    4. XR_004934112.1 RNA Sequence

    5. XR_004934111.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081292.1: Suppressed sequence

      Description
      NM_001081292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66L42.2 GenPept UniProtKB/Swiss-Prot:Q66L42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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