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    Nfasc neurofascin [ Mus musculus (house mouse) ]

    Gene ID: 269116, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Nfascprovided by MGI
    Official Full Name
    neurofascinprovided by MGI
    Primary source
    MGI:MGI:104753
    See related
    Ensembl:ENSMUSG00000026442 AllianceGenome:MGI:104753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NF; mKIAA0756; D430023G06Rik
    Summary
    This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. [provided by RefSeq, May 2009]
    Expression
    Biased expression in cerebellum adult (RPKM 16.4), cortex adult (RPKM 13.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfasc in Genome Data Viewer
    Location:
    1 E4; 1 57.42 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132492428..132669567, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132564690..132741848, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene contactin 2 Neighboring gene predicted gene, 51646 Neighboring gene predicted gene, 46157 Neighboring gene predicted gene 10538 Neighboring gene predicted gene, 31101 Neighboring gene predicted gene, 22609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nodes of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons. Thaxton C, et al. Neuron, 2011 Jan 27. PMID 21262464, Free PMC Article
    2. Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function. Taylor AM, et al. Front Cell Neurosci, 2017. PMID 28217083, Free PMC Article
    3. Neurofascin 186 is O-mannosylated within and outside of the mucin domain. Pacharra S, et al. J Proteome Res, 2012 Aug 3. PMID 22746206
    4. Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment. Ghosh A, et al. Elife, 2020 Sep 9. PMID 32903174, Free PMC Article
    5. Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system. Zonta B, et al. J Cell Biol, 2008 Jun 30. PMID 18573915, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment.
      Title: Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment.
    2. Conditional deletion of the glial isoform Nfasc155 in mice causes severe motor coordination defects and death at 16-17 days after birth.
      Title: Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia.
    3. Study shows that simultaneous ablation of neuronal Neurofascin and Ankyrin G in young and adult mice reveals age-dependent increase in nodal stability in myelinated axons and differential effects on the lifespan.
      Title: Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.
    4. we identify QKI as the long-sought regulator of Neurofascin alternative splicing
      Title: Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.
    5. P0/NFasc Interaction critical for the integrity of paranodal/nodal structures, but not for the stability of myelin
      Title: HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.
    6. Neurofascin 140 is essential for assembly of the node of Ranvier in embryogenesis.
      Title: Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.
    7. In embryonic mouse axons, AnkG is expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. From E11.5 the protein progressively becomes restricted to the proximal axon.
      Title: In vivo assembly of the axon initial segment in motor neurons.
    8. loss of Nfasc155 was sufficient to cause a robust delay in postnatal synapse elimination at the NMJ across all muscle groups examined.
      Title: Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction.
    9. the apparent dependency on sulfatide for maintaining Nfasc155 and MAG associations is intriguing since the fatty acid composition of sulfatide is altered and paranodal ultrastructure is compromised in multiple sclerosis
      Title: Nfasc155H and MAG are specifically susceptible to detergent extraction in the absence of the myelin sphingolipid sulfatide.
    10. Neurofascin is O-mannosylated and the glycosylation sites have been mapped.
      Title: Neurofascin 186 is O-mannosylated within and outside of the mucin domain.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axon guidance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within clustering of voltage-gated sodium channels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within paranodal junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in paranodal junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to juxtaparanode region of axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to paranode region of axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Schwann cell microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in node of Ranvier IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in paranodal junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in paranode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurofascin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160316.1 → NP_001153788.1  neurofascin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The promoter and 5' UTR for this variant have not been determined. The resulting isoform (2) includes the third fibronectin type 3 (FNIII) repeat, lacks the mucin-like domain, and has several differences near the N-terminus, compared to isoform 1. Isoform 2 is also known as NF155, as described by Davis et al. (PMID: 8947556).
      Source sequence(s)
      AC116691, AC159974, AI847023
      UniProtKB/TrEMBL
      A0A087WR56
      Related
      ENSMUSP00000140480.2, ENSMUST00000186389.7
      Conserved Domains (8) summary
      cd05731
      Location:275 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:53 → 129
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:460 → 519
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:264 → 344
      IG_like; Immunoglobulin like
      cd00063
      Location:639 → 729
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:539 → 620
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1081 → 1165
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:134 → 226
      Ig; Immunoglobulin domain

    2. NM_001160317.1 → NP_001153789.1  neurofascin isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) includes the third fibronectin type 3 (FNIII) repeat, lacks the mucin-like domain, and has several differences in the N-terminal and central regions, compared to isoform 1.
      Source sequence(s)
      AC159974, AI847023, AK129207, AK138636, BB659942, BC062092
      Consensus CDS
      CCDS48359.1
      UniProtKB/TrEMBL
      A0A087WR56, E9PW06
      Related
      ENSMUSP00000132979.2, ENSMUST00000163770.8
      Conserved Domains (8) summary
      cd05731
      Location:275 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:53 → 129
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:460 → 519
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:264 → 344
      IG_like; Immunoglobulin like
      cd00063
      Location:624 → 714
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:539 → 620
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1066 → 1150
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:134 → 226
      Ig; Immunoglobulin domain

    3. NM_001160318.1 → NP_001153790.1  neurofascin isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (4) includes the third fibronectin type 3 (FNIII) repeat, lacks the mucin-like domain, and lacks two segments in the N-terminal and central regions, compared to isoform 1.
      Source sequence(s)
      AC159974, AI847023, AK129207, BC062092
      Consensus CDS
      CCDS48358.1
      UniProtKB/TrEMBL
      A0A087WR56, E9Q171
      Related
      ENSMUSP00000035454.8, ENSMUST00000043189.14
      Conserved Domains (8) summary
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:53 → 129
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:443 → 502
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:247 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:607 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:522 → 603
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1049 → 1133
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:134 → 226
      Ig; Immunoglobulin domain

    4. NM_182716.4 → NP_874385.1  neurofascin isoform 1 precursor

      See identical proteins and their annotated locations for NP_874385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This isoform lacks the third fibronectin type 3 (FNIII) repeat and includes the mucin-like domain. Isoform 1 is also known as NF186, as described by Davis et al. (PMID: 8947556).
      Source sequence(s)
      AC116691, AC124095, AC159974, AI847023
      Consensus CDS
      CCDS35707.1
      UniProtKB/Swiss-Prot
      Q810U3
      UniProtKB/TrEMBL
      A0A087WR56
      Related
      ENSMUSP00000092148.5, ENSMUST00000094569.11
      Conserved Domains (10) summary
      cd05731
      Location:264 → 334
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:59 → 135
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:449 → 508
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:729 → 810
      FN3; Fibronectin type 3 domain
      smart00410
      Location:253 → 333
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:528 → 609
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:1015 → 1086
      fn3; Fibronectin type III domain
      pfam13882
      Location:1132 → 1216
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:140 → 232
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132492428..132669567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165385.1 → XP_036021278.1  neurofascin isoform X27

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd00063
      Location:730 → 820
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1060 → 1140
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:456 → 460
      Ig; Ig strand B [structural motif]
      cd05731
      Location:354 → 436
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:246 → 336
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:143 → 237
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:440 → 528
      Ig; Immunoglobulin domain

    2. XM_006529635.4 → XP_006529698.2  neurofascin isoform X4

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:831 → 912
      FN3; Fibronectin type 3 domain
      cd00063
      Location:730 → 820
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:551 → 617
      Ig; Immunoglobulin domain
      cd05731
      Location:366 → 436
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1341 → 1421
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    3. XM_006529653.5 → XP_006529716.2  neurofascin isoform X18

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:709 → 799
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:545 → 611
      Ig; Immunoglobulin domain
      cd05731
      Location:360 → 430
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1151 → 1231
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    4. XM_030254521.2 → XP_030110381.1  neurofascin isoform X7

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:810 → 891
      FN3; Fibronectin type 3 domain
      cd00063
      Location:709 → 799
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:545 → 611
      Ig; Immunoglobulin domain
      cd05731
      Location:360 → 430
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1320 → 1400
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    5. XM_011248013.4 → XP_011246315.1  neurofascin isoform X6

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:825 → 906
      FN3; Fibronectin type 3 domain
      cd00063
      Location:724 → 814
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:545 → 611
      Ig; Immunoglobulin domain
      cd05731
      Location:360 → 430
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1335 → 1415
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    6. XM_030254559.2 → XP_030110419.1  neurofascin isoform X28

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:726 → 816
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:562 → 628
      Ig; Immunoglobulin domain
      cd05731
      Location:377 → 447
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1056 → 1136
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    7. XM_006529651.4 → XP_006529714.2  neurofascin isoform X16

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:726 → 816
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:562 → 628
      Ig; Immunoglobulin domain
      cd05731
      Location:377 → 447
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1163 → 1243
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    8. XM_030254517.2 → XP_030110377.1  neurofascin isoform X5

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:827 → 908
      FN3; Fibronectin type 3 domain
      cd00063
      Location:726 → 816
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:562 → 628
      Ig; Immunoglobulin domain
      cd05731
      Location:377 → 447
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1337 → 1417
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    9. XM_006529646.4 → XP_006529709.2  neurofascin isoform X13

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:741 → 831
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:562 → 628
      Ig; Immunoglobulin domain
      cd05731
      Location:377 → 447
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1183 → 1263
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    10. XM_011248011.3 → XP_011246313.1  neurofascin isoform X2

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:155 → 231
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:842 → 923
      FN3; Fibronectin type 3 domain
      cd00063
      Location:741 → 831
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:562 → 628
      Ig; Immunoglobulin domain
      cd05731
      Location:377 → 447
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1352 → 1432
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:236 → 328
      Ig; Immunoglobulin domain

    11. XM_017320902.2 → XP_017176391.1  neurofascin isoform X26

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:732 → 822
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1062 → 1142
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    12. XM_030254536.2 → XP_030110396.1  neurofascin isoform X15

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:732 → 822
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1169 → 1249
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    13. XM_036165345.1 → XP_036021238.1  neurofascin isoform X14

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd00063
      Location:732 → 822
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1174 → 1254
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:473 → 477
      Ig; Ig strand B [structural motif]
      cd05731
      Location:371 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:246 → 336
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:143 → 237
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:457 → 545
      Ig; Immunoglobulin domain

    14. XM_011248012.3 → XP_011246314.1  neurofascin isoform X3

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:833 → 914
      FN3; Fibronectin type 3 domain
      cd00063
      Location:732 → 822
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1343 → 1423
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    15. XM_017320900.2 → XP_017176389.1  neurofascin isoform X25

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1077 → 1157
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    16. XM_036165357.1 → XP_036021250.1  neurofascin isoform X17

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (8) summary
      smart00060
      Location:848 → 929
      FN3; Fibronectin type 3 domain
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1161 → 1241
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:473 → 477
      Ig; Ig strand B [structural motif]
      cd05731
      Location:371 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:246 → 336
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:143 → 237
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:457 → 545
      Ig; Immunoglobulin domain

    17. XM_011248015.3 → XP_011246317.1  neurofascin isoform X10

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:848 → 929
      FN3; Fibronectin type 3 domain
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1251 → 1331
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    18. XM_011248017.3 → XP_011246319.1  neurofascin isoform X12

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1184 → 1264
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    19. XM_006529644.4 → XP_006529707.2  neurofascin isoform X11

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1189 → 1269
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    20. XM_006529639.5 → XP_006529702.2  neurofascin isoform X8

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:848 → 929
      FN3; Fibronectin type 3 domain
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1279 → 1359
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    21. XM_011248014.3 → XP_011246316.1  neurofascin isoform X9

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (6) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1268 → 1348
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    22. XM_006529634.4 → XP_006529697.2  neurofascin isoform X1

      UniProtKB/TrEMBL
      Q6ZQ54
      Conserved Domains (7) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:848 → 929
      FN3; Fibronectin type 3 domain
      cd00063
      Location:747 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1358 → 1438
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    23. XM_030254557.2 → XP_030110417.1  neurofascin isoform X23

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:723 → 804
      FN3; Fibronectin type 3 domain
      cd00063
      Location:622 → 712
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1115 → 1187
      fn3; Fibronectin type III domain
      pfam13882
      Location:1233 → 1313
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:348 → 352
      Ig; Ig strand B [structural motif]
      cd05731
      Location:246 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:332 → 420
      Ig; Immunoglobulin domain

    24. XM_011248021.1 → XP_011246323.1  neurofascin isoform X20

      See identical proteins and their annotated locations for XP_011246323.1

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:740 → 821
      FN3; Fibronectin type 3 domain
      cd00063
      Location:639 → 729
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1132 → 1204
      fn3; Fibronectin type III domain
      pfam13882
      Location:1250 → 1330
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:365 → 369
      Ig; Ig strand B [structural motif]
      cd05731
      Location:263 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:349 → 437
      Ig; Immunoglobulin domain

    25. XM_011248019.2 → XP_011246321.1  neurofascin isoform X19

      See identical proteins and their annotated locations for XP_011246321.1

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:746 → 827
      FN3; Fibronectin type 3 domain
      cd00063
      Location:645 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1138 → 1210
      fn3; Fibronectin type III domain
      pfam13882
      Location:1256 → 1336
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:371 → 375
      Ig; Ig strand B [structural motif]
      cd05731
      Location:269 → 351
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:144 → 234
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:41 → 135
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:355 → 443
      Ig; Immunoglobulin domain

    26. XM_030254547.1 → XP_030110407.1  neurofascin isoform X20

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:740 → 821
      FN3; Fibronectin type 3 domain
      cd00063
      Location:639 → 729
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1132 → 1204
      fn3; Fibronectin type III domain
      pfam13882
      Location:1250 → 1330
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:365 → 369
      Ig; Ig strand B [structural motif]
      cd05731
      Location:263 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:349 → 437
      Ig; Immunoglobulin domain

    27. XM_030254549.2 → XP_030110409.1  neurofascin isoform X21

      UniProtKB/TrEMBL
      A0A087WPX3, A0A087WR56
      Related
      ENSMUSP00000139955.2, ENSMUST00000187861.7
      Conserved Domains (7) summary
      cd05875
      Location:59 → 135
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:729 → 810
      FN3; Fibronectin type 3 domain
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:449 → 515
      Ig; Immunoglobulin domain
      cd05731
      Location:264 → 334
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1239 → 1319
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:140 → 232
      Ig; Immunoglobulin domain

    28. XM_011248024.4 → XP_011246326.1  neurofascin isoform X19

      See identical proteins and their annotated locations for XP_011246326.1

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:746 → 827
      FN3; Fibronectin type 3 domain
      cd00063
      Location:645 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1138 → 1210
      fn3; Fibronectin type III domain
      pfam13882
      Location:1256 → 1336
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:371 → 375
      Ig; Ig strand B [structural motif]
      cd05731
      Location:269 → 351
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:144 → 234
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:41 → 135
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:355 → 443
      Ig; Immunoglobulin domain

    29. XM_036165375.1 → XP_036021268.1  neurofascin isoform X23

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:723 → 804
      FN3; Fibronectin type 3 domain
      cd00063
      Location:622 → 712
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1115 → 1187
      fn3; Fibronectin type III domain
      pfam13882
      Location:1233 → 1313
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:348 → 352
      Ig; Ig strand B [structural motif]
      cd05731
      Location:246 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:332 → 420
      Ig; Immunoglobulin domain

    30. XM_011248020.4 → XP_011246322.1  neurofascin isoform X20

      See identical proteins and their annotated locations for XP_011246322.1

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:740 → 821
      FN3; Fibronectin type 3 domain
      cd00063
      Location:639 → 729
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1132 → 1204
      fn3; Fibronectin type III domain
      pfam13882
      Location:1250 → 1330
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:365 → 369
      Ig; Ig strand B [structural motif]
      cd05731
      Location:263 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:349 → 437
      Ig; Immunoglobulin domain

    31. XM_036165362.1 → XP_036021255.1  neurofascin isoform X19

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:746 → 827
      FN3; Fibronectin type 3 domain
      cd00063
      Location:645 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1138 → 1210
      fn3; Fibronectin type III domain
      pfam13882
      Location:1256 → 1336
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:371 → 375
      Ig; Ig strand B [structural motif]
      cd05731
      Location:269 → 351
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:144 → 234
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:41 → 135
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:355 → 443
      Ig; Immunoglobulin domain

    32. XM_011248023.2 → XP_011246325.1  neurofascin isoform X19

      See identical proteins and their annotated locations for XP_011246325.1

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:746 → 827
      FN3; Fibronectin type 3 domain
      cd00063
      Location:645 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1138 → 1210
      fn3; Fibronectin type III domain
      pfam13882
      Location:1256 → 1336
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:371 → 375
      Ig; Ig strand B [structural motif]
      cd05731
      Location:269 → 351
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:144 → 234
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:41 → 135
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:355 → 443
      Ig; Immunoglobulin domain

    33. XM_030254562.1 → XP_030110422.1  neurofascin isoform X29

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (6) summary
      cd05875
      Location:53 → 129
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00063
      Location:624 → 714
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:460 → 526
      Ig; Immunoglobulin domain
      cd05731
      Location:275 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1061 → 1141
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:134 → 226
      Ig; Immunoglobulin domain

    34. XM_030254551.1 → XP_030110411.1  neurofascin isoform X22

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (7) summary
      cd05875
      Location:53 → 129
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:725 → 806
      FN3; Fibronectin type 3 domain
      cd00063
      Location:624 → 714
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:460 → 526
      Ig; Immunoglobulin domain
      cd05731
      Location:275 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      pfam13882
      Location:1235 → 1315
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:134 → 226
      Ig; Immunoglobulin domain

    35. XM_036165369.1 → XP_036021262.1  neurofascin isoform X20

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:740 → 821
      FN3; Fibronectin type 3 domain
      cd00063
      Location:639 → 729
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1132 → 1204
      fn3; Fibronectin type III domain
      pfam13882
      Location:1250 → 1330
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:365 → 369
      Ig; Ig strand B [structural motif]
      cd05731
      Location:263 → 345
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:349 → 437
      Ig; Immunoglobulin domain

    36. XM_036165381.1 → XP_036021274.1  neurofascin isoform X24

      UniProtKB/TrEMBL
      A0A087WR56
      Conserved Domains (9) summary
      smart00060
      Location:708 → 789
      FN3; Fibronectin type 3 domain
      cd00063
      Location:607 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1100 → 1172
      fn3; Fibronectin type III domain
      pfam13882
      Location:1218 → 1298
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:348 → 352
      Ig; Ig strand B [structural motif]
      cd05731
      Location:246 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05845
      Location:138 → 228
      IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05875
      Location:35 → 129
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:332 → 420
      Ig; Immunoglobulin domain

    37. XM_011248025.3 → XP_011246327.1  neurofascin isoform X30

      Conserved Domains (5) summary
      smart00060
      Location:388 → 469
      FN3; Fibronectin type 3 domain
      cd00063
      Location:287 → 377
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:108 → 174
      Ig; Immunoglobulin domain
      pfam13882
      Location:898 → 978
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:39 → 85
      Ig; Immunoglobulin domain

    38. XM_017320909.3 → XP_017176398.1  neurofascin isoform X31

      UniProtKB/TrEMBL
      A0A9Y2YA21
      Conserved Domains (4) summary
      cd05875
      Location:161 → 237
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      cd00096
      Location:568 → 634
      Ig; Immunoglobulin domain
      cd05731
      Location:383 → 453
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cl11960
      Location:242 → 334
      Ig; Immunoglobulin domain

    RNA

    1. XR_387171.5 RNA Sequence

    2. XR_001784700.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810U3.1 GenPept UniProtKB/Swiss-Prot:Q810U3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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