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    Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [ Mus musculus (house mouse) ]

    Gene ID: 268930, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pkmyt1provided by MGI
    Official Full Name
    protein kinase, membrane associated tyrosine/threonine 1provided by MGI
    Primary source
    MGI:MGI:2137630
    See related
    Ensembl:ENSMUSG00000023908 AllianceGenome:MGI:2137630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myt1; 6230424P17
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; early embryo; oocyte; retina; and thymus primordium. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 44.6), testis adult (RPKM 32.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pkmyt1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.02 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23945385..23955709)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23726336..23736735)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene claudin 9 Neighboring gene glycine rich extracellular protein 1 Neighboring gene progestin and adipoQ receptor family member IV Neighboring gene kringle containing transmembrane protein 2 Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene FLYWCH-type zinc finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Oh JS, et al. Science, 2011 Apr 22. PMID 21454751, Free PMC Article
    2. ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer. Yang L, et al. Cell Oncol (Dordr), 2023 Aug. PMID 36988891
    3. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. Oh JS, et al. J Cell Biol, 2010 Jan 25. PMID 20083600, Free PMC Article
    4. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
    5. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
      Title: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
    Names
    MYT1 kinase
    NP_001405406.1
    NP_001405409.1
    NP_001405413.1
    NP_001405414.1
    NP_001405456.1
    NP_001405457.1
    NP_001405458.1
    NP_075545.2
    XP_006524373.1
    XP_006524374.1
    XP_030105683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418477.1 → NP_001405406.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122821

    2. NM_001418480.1 → NP_001405409.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122821

    3. NM_001418484.1 → NP_001405413.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122821

    4. NM_001418485.1 → NP_001405414.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122821

    5. NM_001418527.1 → NP_001405456.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122821

    6. NM_001418528.1 → NP_001405457.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122821

    7. NM_001418529.1 → NP_001405458.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122821

    8. NM_023058.4 → NP_075545.2  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

      See identical proteins and their annotated locations for NP_075545.2

      Status: VALIDATED

      Source sequence(s)
      AC122821
      Consensus CDS
      CCDS28460.1
      UniProtKB/Swiss-Prot
      Q3TNN2, Q8R3L4, Q9ESG9
      Related
      ENSMUSP00000024701.8, ENSMUST00000024701.9
      Conserved Domains (2) summary
      smart00220
      Location:101 → 350
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14050
      Location:99 → 348
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23945385..23955709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524310.4 → XP_006524373.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

      Conserved Domains (1) summary
      cd14050
      Location:148 → 397
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

    2. XM_006524311.5 → XP_006524374.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

      Conserved Domains (1) summary
      cd14050
      Location:148 → 397
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

    3. XM_030249823.2 → XP_030105683.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 216
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESG9.3 GenPept UniProtKB/Swiss-Prot:Q9ESG9

    Gene LinkOut

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