Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnc2provided by MGI
Official Full Name: potassium voltage gated channel, Shaw-related subfamily, member 2provided by MGI
Primary source: MGI:MGI:96668
See related: Ensembl:ENSMUSG00000035681 AllianceGenome:MGI:96668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv3.2; KShIIIA; B230117I07
Summary: Enables transmembrane transporter binding activity and voltage-gated potassium channel activity. Involved in membrane hyperpolarization; potassium ion transport; and regulation of action potential firing rate. Acts upstream of or within action potential. Located in several cellular components, including neuronal cell body membrane; perikaryon; and synaptic membrane. Is expressed in several structures, including brain; genitourinary system; gut; spinal cord; and trigeminal nerve. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 4.9), frontal lobe adult (RPKM 4.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 60.3 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (112105803..112302209)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (112269898..112466304)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although all Kv3 transcripts were significantly expressed in embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins aree present, suggesting a novel role for Kv3 channels at this developmental stage.
Title: Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.
Mice lacking both Kcnc1 and Kcnc2 genes fail to express the Kv3.1 and Kv3.2 channels in in the suprachiasmatic nucleus.
Title: Fast delayed rectifier potassium current: critical for input and output of the circadian system.
Kv3.2, Kv1, SK potassium and N-type calcium channels strongly regulate thalamic relay neuron sensory transmission and that each channel subtype controls a different stimulus-response curve property.
Title: Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels.
Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.2 channel.
Title: A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina.
Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons.
Title: Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons.
Kv3.2 expression became detectable in the lumbar cord from postnatal day 12, and increased steadily until reaching an adult level at postnatal day 28. In contrast to the Kv3.1b results, Kv3.2 was not expressed in Renshaw cells.
Title: Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

08.MMHAP84FLC2.seq (e-PCR)
- UniSTS:122949

G67041 (e-PCR)
- UniSTS:178249

AW047325 (e-PCR)
- UniSTS:164449

BF404636 (e-PCR)
- UniSTS:247153

05.MMHAP36FRB8.seq (e-PCR)
- UniSTS:122811

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ammonium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitric oxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in globus pallidus development	IEA Inferred from Electronic Annotation more info
involved_in membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide-cGMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic nerve development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of action potential firing rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to amine	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to light intensity	IEA Inferred from Electronic Annotation more info
involved_in response to magnesium ion	IEA Inferred from Electronic Annotation more info
involved_in response to nerve growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated potassium channel KCNC2; potassium voltage-gated channel subfamily C member 2

Names: shaw-like potassium channel; voltage-gated potassium channel Kv3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025581.1 → NP_001020752.1 voltage-gated potassium channel KCNC2 isoform 2

See identical proteins and their annotated locations for NP_001020752.1

Status: VALIDATED

Source sequence(s)

AC121610, AK045425, BB641820

Consensus CDS

CCDS24173.1

UniProtKB/TrEMBL

A0A1W2P796

Related

ENSMUSP00000151579.2, ENSMUST00000219301.2

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
NM_001359752.1 → NP_001346681.1 voltage-gated potassium channel KCNC2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121610, AI835316, BC116289

Consensus CDS

CCDS88085.1

UniProtKB/Swiss-Prot

Q14B80

Related

ENSMUSP00000089814.4, ENSMUST00000092175.4

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
NM_001359753.1 → NP_001346682.1 voltage-gated potassium channel KCNC2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121610, AC153500, AI835316, BC116289

Consensus CDS

CCDS88085.1

UniProtKB/Swiss-Prot

Q14B80

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
NM_001379643.1 → NP_001366572.1 voltage-gated potassium channel KCNC2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121610, AC153500

UniProtKB/Swiss-Prot

Q14B80

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
NM_001379644.1 → NP_001366573.1 voltage-gated potassium channel KCNC2 isoform 3

Status: VALIDATED

Source sequence(s)

AC121610, AC153500

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

112105803..112302209

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513693.5 → XP_006513756.1 potassium voltage-gated channel subfamily C member 2 isoform X4

See identical proteins and their annotated locations for XP_006513756.1

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_006513692.4 → XP_006513755.1 potassium voltage-gated channel subfamily C member 2 isoform X4

See identical proteins and their annotated locations for XP_006513755.1

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_006513695.5 → XP_006513758.1 potassium voltage-gated channel subfamily C member 2 isoform X5

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_011243455.3 → XP_011241757.1 potassium voltage-gated channel subfamily C member 2 isoform X2

See identical proteins and their annotated locations for XP_011241757.1

UniProtKB/TrEMBL

A0A1W2P796

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_006513691.4 → XP_006513754.1 potassium voltage-gated channel subfamily C member 2 isoform X3

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_006513694.5 → XP_006513757.1 potassium voltage-gated channel subfamily C member 2 isoform X4

See identical proteins and their annotated locations for XP_006513757.1

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_006513687.5 → XP_006513750.1 potassium voltage-gated channel subfamily C member 2 isoform X1

See identical proteins and their annotated locations for XP_006513750.1

UniProtKB/Swiss-Prot

Q14B80

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_006513690.3 → XP_006513753.1 potassium voltage-gated channel subfamily C member 2 isoform X1

See identical proteins and their annotated locations for XP_006513753.1

UniProtKB/Swiss-Prot

Q14B80

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_036155791.1 → XP_036011684.1 potassium voltage-gated channel subfamily C member 2 isoform X3

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_030245096.1 → XP_030100956.1 potassium voltage-gated channel subfamily C member 2 isoform X1

UniProtKB/Swiss-Prot

Q14B80

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_017313951.3 → XP_017169440.1 potassium voltage-gated channel subfamily C member 2 isoform X4

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_036155792.1 → XP_036011685.1 potassium voltage-gated channel subfamily C member 2 isoform X4

Conserved Domains (2) summary

cd18415
Location:7 → 170

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:232 → 488

Ion_trans; Ion transport protein
XM_011243456.4 → XP_011241758.1 potassium voltage-gated channel subfamily C member 2 isoform X6

Conserved Domains (1) summary

pfam00520
Location:31 → 288

Ion_trans; Ion transport protein