Alk ALK receptor tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Alkprovided by RGD
Full Name: ALK receptor tyrosine kinaseprovided by RGD
Primary source: RGD:628622
See related: Ensembl:ENSRNOG00000008683 AllianceGenome:RGD:628622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in nervous system development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 8.9), Spleen (RPKM 2.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (28631431..29351321)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (22879653..23599636)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (22696415..23203791)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Electroretinography b-wave amplitude decreases during dark adaption following crizotinib administration may be related to signaling changes within the retina in rats, likely independent of ALK inhibition.
Title: Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition.
We showed that ALK is specifically present in a subtype of neurons during DRG development, and that the majority of these neurons co-expressed TrkA and Ret.
Title: ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.
analysis of differentiation of PC12 cells and human embryonic kidney 293 cells transfected with ALK shows absence of agonist activity of pleiotrophin
Title: Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.
ALK has a proapoptotic activity in the absence of ligand, whereas it is antiapoptotic in the presence of its ligand and when the kinase is intrinsically activated.
Title: Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138197 (e-PCR)
- UniSTS:220284

D6Got14 (e-PCR)
- UniSTS:114050

RH131901 (e-PCR)
- UniSTS:215184

D6Got12 (e-PCR)
- UniSTS:114606

RH136724 (e-PCR)
- UniSTS:218813

D6Rat54 (e-PCR)
- UniSTS:118984

AU048193 (e-PCR)
- UniSTS:109779

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to environmental enrichment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within swimming behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ALK tyrosine kinase receptor

Names: ALK tyrosine kinase receptor-like; anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase

NP_001162572.1

EC 2.7.10.1

XP_038967747.1

EC 2.7.10.1

XP_063117641.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169101.3 → NP_001162572.1 ALK tyrosine kinase receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

F1LRZ0

Related

ENSRNOP00000011630.7, ENSRNOT00000011630.7

Conserved Domains (5) summary

cd06263
Location:484 → 635

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

cd05036
Location:1113 → 1389

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam00629
Location:484 → 640

MAM; MAM domain, meprin/A5/mu

pfam07714
Location:1120 → 1387

Pkinase_Tyr; Protein tyrosine kinase

pfam14670
Location:991 → 1025

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

28631431..29351321

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111819.2 → XP_038967747.1 ALK tyrosine kinase receptor isoform X1

Conserved Domains (3) summary

PRK12323
Location:969 → 1138

PRK12323; DNA polymerase III subunit gamma/tau

cd05036
Location:675 → 951

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam00629
Location:46 → 201

MAM; MAM domain, meprin/A5/mu
XM_063261571.1 → XP_063117641.1 ALK tyrosine kinase receptor isoform X2