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    CKAP2 cytoskeleton associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 26586, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CKAP2provided by HGNC
    Official Full Name
    cytoskeleton associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:1990
    See related
    Ensembl:ENSG00000136108 MIM:611569; AllianceGenome:HGNC:1990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LB1; TMAP; se20-10
    Summary
    This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in bone marrow (RPKM 15.6), testis (RPKM 14.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CKAP2 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52455478..52476627)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51670301..51692112)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53029613..53050762)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 homolog Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53024355-53024935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7791 Neighboring gene CKAP2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 345 Neighboring gene TPTE2 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 15313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7793 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Condensed chromatin staining of CKAP2 as surrogate marker for mitotic figures. Kim HS, et al. J Cancer Res Clin Oncol, 2012 Jan. PMID 22020800
    2. CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma. Wang K, et al. Oncol Rep, 2018 Oct. PMID 30066946, Free PMC Article
    3. Silencing of cytoskeleton-associated protein 2 represses cell proliferation and induces cell cycle arrest and cell apoptosis in osteosarcoma cells. Zhang S, et al. Biomed Pharmacother, 2018 Oct. PMID 30119212
    4. Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein. Hong KU, et al. Exp Mol Med, 2009 Nov 30. PMID 19641375, Free PMC Article
    5. CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit. Seki A, et al. J Biol Chem, 2007 May 18. PMID 17376772

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma.
      Title: CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma.
    2. Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1alpha-induced transcription of CKAP2.
      Title: Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1α-induced transcription of CKAP2.
    3. LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis.
      Title: LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis.
    4. Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.
      Title: Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.
    5. CKAP2 acts as a functional oncogene in cervical carcinoma development and may exert its function by targeting FAK-ERK2 signaling pathway.
      Title: Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines.
    6. Knockdown of CKAP2 expression effectively suppressed the proliferation and induced the apoptosis by inhibiting the phosphorylation of JAK2/STAT3 of osteosarcoma cells.
      Title: Silencing of cytoskeleton-associated protein 2 represses cell proliferation and induces cell cycle arrest and cell apoptosis in osteosarcoma cells.
    7. High CKAP2 expression is associated with highgrade glioma.
      Title: CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma.
    8. High CKAP2 expression is associated with Ovarian Cancer.
      Title: CKAP2 Promotes Ovarian Cancer Proliferation and Tumorigenesis Through the FAK-ERK Pathway.
    9. Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.
      Title: Chromatin CKAP2, a new proliferation marker, as independent prognostic indicator in breast cancer.
    10. The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.
      Title: RHOA, SEMA3B, and CKAP2 expression in leukaemia of different types: the results of a pilot experiment.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10749, DKFZp686L1238

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoskeleton-associated protein 2
    Names
    CTCL tumor antigen se20-10
    tumor- and microtubule-associated protein
    tumor-associated microtubule-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098525.3 → NP_001091995.1  cytoskeleton-associated protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001091995.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AI499799, AY062261, EC439890, Y15758
      Consensus CDS
      CCDS41893.1
      UniProtKB/Swiss-Prot
      A2BDE0, A5YM58, B4DR35, E9PD90, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q8WWK9, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4
      UniProtKB/TrEMBL
      B2RMQ4
      Related
      ENSP00000367276.4, ENST00000378037.9
      Conserved Domains (1) summary
      pfam15297
      Location:326 → 673
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    2. NM_001286686.2 → NP_001273615.1  cytoskeleton-associated protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI499799, AK299083, AY062261, EC439890
      Consensus CDS
      CCDS66557.1
      UniProtKB/TrEMBL
      B2RMQ4
      Related
      ENSP00000417830.1, ENST00000490903.5
      Conserved Domains (1) summary
      pfam15297
      Location:277 → 624
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    3. NM_001286687.2 → NP_001273616.1  cytoskeleton-associated protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001273616.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as CKAP2-s) lacks multiple 3' coding exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA308726, AY062262
      Consensus CDS
      CCDS73578.1
      UniProtKB/Swiss-Prot
      Q8WWK9
      Related
      ENSP00000367273.2, ENST00000378034.7
      Conserved Domains (1) summary
      pfam15297
      Location:325 → 492
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    4. NM_018204.5 → NP_060674.3  cytoskeleton-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_060674.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI499799, AK022982, AY062261, EC439890
      Consensus CDS
      CCDS9435.1
      UniProtKB/TrEMBL
      B2RMQ4
      Related
      ENSP00000258607.5, ENST00000258607.10
      Conserved Domains (1) summary
      pfam15297
      Location:325 → 672
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      52455478..52476627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266344.5 → XP_005266401.1  cytoskeleton-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RMQ4
      Conserved Domains (1) summary
      pfam15297
      Location:278 → 625
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    2. XM_047430268.1 → XP_047286224.1  cytoskeleton-associated protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      51670301..51692112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374449.1 → XP_054230424.1  cytoskeleton-associated protein 2 isoform X1

    2. XM_054374450.1 → XP_054230425.1  cytoskeleton-associated protein 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWK9.1 GenPept UniProtKB/Swiss-Prot:Q8WWK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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