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    Rpl27a ribosomal protein L27A [ Mus musculus (house mouse) ]

    Gene ID: 26451, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Rpl27aprovided by MGI
    Official Full Name
    ribosomal protein L27Aprovided by MGI
    Primary source
    MGI:MGI:1347076
    See related
    Ensembl:ENSMUSG00000046364 AllianceGenome:MGI:1347076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L29; L27'; L27A
    Summary
    A structural constituent of ribosome. Acts upstream of or within translation. Located in cytosolic ribosome. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in endolymphatic appendage and head. Orthologous to human RPL27A (ribosomal protein L27a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 331.7), liver E14.5 (RPKM 304.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl27a in Genome Data Viewer
    Location:
    7 E3; 7 57.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109118354..109121967)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109519195..109522369)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 Neighboring gene RIKEN cDNA 1700095J03 gene Neighboring gene tripartite motif-containing 66 Neighboring gene STARR-seq mESC enhancer starr_19797 Neighboring gene predicted gene, 24888 Neighboring gene DENN domain containing 2B Neighboring gene small nucleolar RNA, H/ACA box 3 Neighboring gene STARR-seq mESC enhancer starr_19802 Neighboring gene STARR-seq mESC enhancer starr_19804 Neighboring gene STARR-positive B cell enhancer ABC_E4965 Neighboring gene VISTA enhancer mm1407 Neighboring gene cDNA sequence BC051019 Neighboring gene A kinase interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. Kusuda J, et al. Cytogenet Cell Genet, 1999. PMID 10449908
    2. Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Belhumeur P, et al. Nucleic Acids Res, 1987 Feb 11. PMID 2434927, Free PMC Article
    3. Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. Fleming G, et al. Proc Natl Acad Sci U S A, 1989 Jan. PMID 2643099, Free PMC Article
    4. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. Terzian T, et al. J Pathol, 2011 Aug. PMID 21674502, Free PMC Article
    5. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. Michalik L, et al. J Cell Biol, 2001 Aug 20. PMID 11514592, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66730, MGC107695

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL15
    Names
    60S ribosomal protein L27a
    ribosomal protein L29 homolog
    NP_036105.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011975.4 → NP_036105.2  large ribosomal subunit protein uL15

      See identical proteins and their annotated locations for NP_036105.2

      Status: VALIDATED

      Source sequence(s)
      AC124457
      Consensus CDS
      CCDS40083.1
      UniProtKB/Swiss-Prot
      P14115, Q9CQ16, Q9R1X6
      Related
      ENSMUSP00000123410.2, ENSMUST00000143107.2
      Conserved Domains (1) summary
      PTZ00160
      Location:1 → 148
      PTZ00160; 60S ribosomal protein L27a; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109118354..109121967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14115.5 GenPept UniProtKB/Swiss-Prot:P14115

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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