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    Ifi202b interferon activated gene 202B [ Mus musculus (house mouse) ]

    Gene ID: 26388, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ifi202bprovided by MGI
    Official Full Name
    interferon activated gene 202Bprovided by MGI
    Primary source
    MGI:MGI:1347083
    See related
    Ensembl:ENSMUSG00000026535 AllianceGenome:MGI:1347083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p202; Ifi202; Ifbip-1; Ifi202a; Ifi202c
    Summary
    Acts upstream of or within cellular response to interferon-beta. Is expressed in bone; decidua; epidermis; and thymus primordium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Ifi202b in Genome Data Viewer
    Location:
    1; 1 H3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173790135..173810410, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173962569..173982844, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interferon activated gene 211 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene interferon activated gene 203 Neighboring gene STARR-positive B cell enhancer ABC_E3335 Neighboring gene STARR-positive B cell enhancer ABC_E11109 Neighboring gene interferon activated gene 204 pseudogene Neighboring gene predicted gene, 53482

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. Ma XY, et al. J Biol Chem, 2003 Jun 20. PMID 12676938
    2. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. Xin H, et al. J Immunol, 2006 May 15. PMID 16670293
    3. Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes. Cao Y, et al. J Immunol Res, 2018. PMID 30246031, Free PMC Article
    4. Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Yamauchi M, et al. Int Immunol, 2007 Aug. PMID 17702989
    5. The interferon-inducible protein p202 promotes osteogenesis in mouse bone marrow stromal cells. Zhang L, et al. Biosci Rep, 2018 Jun 29. PMID 29853536, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth.
      Title: IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth.
    2. Enforced expression of IFI16-b inhibits the activation of AIM2 inflammasome, whereas knockdown of IFI16-b augments interleukin-1b secretion triggered by dsDNA but not dsRNA Thus, cytoplasm-localized IFI16-b is functionally equivalent to mouse p202 that exerts an inhibitory effect on AIM2 inflammasome. .
      Title: Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16.
    3. p202 promotes osteogenesis in mouse bone marrow stromal cells.
      Title: The interferon-inducible protein p202 promotes osteogenesis in mouse bone marrow stromal cells.
    4. Ifi202b and IFI16 have roles as obesity genes
      Title: Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans.
    5. the expression level of Ifi202b showed the most sex difference in correlation with known immune-related genes
      Title: Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes.
    6. These results, together with the reported data on p202 HINb, lead to an interaction model for full-length p202 and dsDNA which provides a conceivable mechanism for the negative regulation of Aim2 inflammasome activation by p202.
      Title: Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling.
    7. p202 plays a role in mouse adipose-derived stem cell adipogenesis.
      Title: Role of interferon-inducible protein 202 (p202) in the regulation of adipogenesis in mouse adipose-derived stem cells.
    8. Authors hypothesize that while p202 was evolutionarily selected to limit AIM2-mediated inflammation in some mouse strains, the same mechanism contributes to increased interferon production and lupus susceptibility.
      Title: Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
    9. Ifi202b modulates fat accumulation through expression of adipogenic genes such as 11beta-Hsd1.
      Title: Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity.
    10. Studies identify p202 as a regulator of murine BAFF.
      Title: Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-activable protein 202
    Names
    Interferon-activatable protein 202a (Ifi-202a) (Interferon-inducible protein p202a)
    ifi-202
    interferon activated gene 202A
    interferon-inducible protein p202
    lupus susceptibility protein p202

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008327.2 → NP_032353.2  interferon-activable protein 202

      See identical proteins and their annotated locations for NP_032353.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC170584, CJ056241, EL957871, M31418
      Consensus CDS
      CCDS35794.1
      UniProtKB/Swiss-Prot
      E9QLD9, P15091, Q38JF1, Q7TMN6, Q8VEL7, Q9R002
      UniProtKB/TrEMBL
      A0A1Z3MHY1
      Related
      ENSMUSP00000000266.8, ENSMUST00000000266.9
      Conserved Domains (1) summary
      pfam02760
      Location:58 → 223
      HIN; HIN-200/IF120x domain

    2. NM_011940.2 → NP_036070.2  interferon-activable protein 202

      See identical proteins and their annotated locations for NP_036070.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC170584, CJ045697, CJ056241, EL957871, M31418
      Consensus CDS
      CCDS35794.1
      UniProtKB/Swiss-Prot
      E9QLD9, P15091, Q38JF1, Q7TMN6, Q8VEL7, Q9R002
      UniProtKB/TrEMBL
      A0A1Z3MHY1
      Conserved Domains (1) summary
      pfam02760
      Location:58 → 223
      HIN; HIN-200/IF120x domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173790135..173810410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R002.3 GenPept UniProtKB/Swiss-Prot:Q9R002

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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