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    Angptl2 angiopoietin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 26360, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Angptl2provided by MGI
    Official Full Name
    angiopoietin-like 2provided by MGI
    Primary source
    MGI:MGI:1347002
    See related
    Ensembl:ENSMUSG00000004105 AllianceGenome:MGI:1347002
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp2
    Summary
    Predicted to enable signaling receptor binding activity. Located in extracellular space. Is expressed in several structures, including brain; intraembryonic coelom; limb segment; meninges; and skeleton. Used to study dermatomyositis. Orthologous to human ANGPTL2 (angiopoietin like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 99.1), subcutaneous fat pad adult (RPKM 61.8) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Angptl2 in Genome Data Viewer
    Location:
    2 B; 2 22.36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33105963..33137737)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33215951..33247725)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene predicted gene 13528 Neighboring gene predicted gene, 23546 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene predicted gene 13536 Neighboring gene zinc finger and BTB domain containing 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis. Horiguchi H, et al. Commun Biol, 2023 Sep 22. PMID 37736764, Free PMC Article
    2. Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye. Kanda A, et al. Lab Invest, 2012 Nov. PMID 22868908
    3. Angiopoietin-like protein 2 is a potent hemangiogenic and lymphangiogenic factor in corneal inflammation. Toyono T, et al. Invest Ophthalmol Vis Sci, 2013 Jun 26. PMID 23702783
    4. Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Aoi J, et al. Cancer Res, 2011 Dec 15. PMID 22042794
    5. ANGPTL2 promotes tumor metastasis in hepatocellular carcinoma. Gao L, et al. J Gastroenterol Hepatol, 2015 Feb. PMID 25090954

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2.
      Title: ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2.
    2. ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
      Title: ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
    3. ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
      Title: ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
    4. ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
      Title: ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
    5. ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
      Title: ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
    6. Angiopoietin-like 2 is essential to aortic valve development in mice.
      Title: Angiopoietin-like 2 is essential to aortic valve development in mice.
    7. Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis.
      Title: Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.
    8. Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
      Title: Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
    9. Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
      Title: Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
    10. ANGPTL2 Promotes Inflammation via Integrin alpha5beta1 in Chondrocytes.
      Title: ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 2
    Names
    angiopoietin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011923.4 → NP_036053.2  angiopoietin-related protein 2 precursor

      See identical proteins and their annotated locations for NP_036053.2

      Status: PROVISIONAL

      Source sequence(s)
      AK155464
      Consensus CDS
      CCDS15940.1
      UniProtKB/Swiss-Prot
      Q8BM09, Q9R045
      Related
      ENSMUSP00000004208.6, ENSMUST00000004208.7
      Conserved Domains (2) summary
      smart00397
      Location:156 → 206
      t_SNARE; Helical region found in SNAREs
      cd00087
      Location:273 → 487
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      33105963..33137737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498051.1 → XP_006498114.1  angiopoietin-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006498114.1

      UniProtKB/Swiss-Prot
      Q8BM09, Q9R045
      Conserved Domains (2) summary
      smart00397
      Location:156 → 206
      t_SNARE; Helical region found in SNAREs
      cd00087
      Location:273 → 487
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R045.2 GenPept UniProtKB/Swiss-Prot:Q9R045

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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