Cadm4 cell adhesion molecule 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cadm4provided by MGI
Official Full Name: cell adhesion molecule 4provided by MGI
Primary source: MGI:MGI:2449088
See related: Ensembl:ENSMUSG00000054793 AllianceGenome:MGI:2449088
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsll2; Igdf4c; Igsf4c
Summary: Enables enzyme binding activity and vascular endothelial growth factor receptor binding activity. Involved in several processes, including negative regulation of cellular response to growth factor stimulus; negative regulation of protein phosphorylation; and regulation of Rac protein signal transduction. Predicted to be located in cell leading edge. Predicted to be active in cell-cell contact zone. Is expressed in dentate gyrus subgranular zone; dorsal root ganglion; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human CADM4 (cell adhesion molecule 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 63.0), cerebellum adult (RPKM 62.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 11.03 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24181448..24203958)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24482023..24504533)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Indispensable role of Nectin-like 4 in regulating synapse-related molecules, synaptic structure, and individual behavior.
Title: Indispensable role of Nectin-like 4 in regulating synapse-related molecules, synaptic structure, and individual behavior.
Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35.
Title: Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35.
The results of this study demonstrate that tightly regulated axon-glia adhesion by Cadm4 Regulates CNS Myelination.
Title: Axoglial Adhesion by Cadm4 Regulates CNS Myelination.
Necl-4 is dispensable for axonal myelination in the developing nervous system.
Title: Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination.
findings imply that 4.1G plays a role in spermatogenesis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with NECL4 on Sertoli cells
Title: Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH36722 (e-PCR)
- UniSTS:84570

IGSF4C__6451 (e-PCR)
- UniSTS:468478

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule 4

Names: NECL-4; SynCAM 4; TSLC1-like 2; TSLC1-like protein 2; immunoglobulin superfamily, member 4C; membrane glycoprotein Tsll2; nectin-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153112.3 → NP_694752.1 cell adhesion molecule 4 precursor

See identical proteins and their annotated locations for NP_694752.1

Status: PROVISIONAL

Source sequence(s)

AK143204

Consensus CDS

CCDS20951.1

UniProtKB/Swiss-Prot

Q8R464

Related

ENSMUSP00000066880.8, ENSMUST00000068023.8

Conserved Domains (3) summary

smart00294
Location:344 → 362

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:237 → 298

IGc2; Immunoglobulin C-2 Type

cl11960
Location:140 → 220

Ig; Immunoglobulin domain