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    Frmd6 FERM domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 257646, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Frmd6provided by RGD
    Official Full Name
    FERM domain containing 6provided by RGD
    Primary source
    RGD:727810
    See related
    EnsemblRapid:ENSRNOG00000007329 AllianceGenome:RGD:727810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within apical constriction; protein localization; and regulation of actin filament-based process. Predicted to be located in apical junction complex; cytoplasm; and plasma membrane. Orthologous to human FRMD6 (FERM domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 142.9), Adrenal (RPKM 134.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmd6 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (95081958..95155561)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (89345983..89419579)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (93281382..93358888)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552060 Neighboring gene uncharacterized LOC134479217 Neighboring gene small nucleolar RNA, C/D box 45 like 1 Neighboring gene transfer RNA alanine (anticodon AGC) 24 Neighboring gene actin related protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FERM domain-containing protein 6 identifies a subpopulation of varicose nerve fibers in different vertebrate species. Beck J, et al. Cell Tissue Res, 2020 Jul. PMID 32200438, Free PMC Article
    2. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Ishiuchi T, et al. Nat Cell Biol, 2011 Jun 19. PMID 21685893
    3. Nectins localize Willin to cell-cell junctions. Ishiuchi T, et al. Genes Cells, 2012 May. PMID 22512338
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FERM domain-containing protein 6 identifies a subpopulation of varicose nerve fibers in different vertebrate species.
      Title: FERM domain-containing protein 6 identifies a subpopulation of varicose nerve fibers in different vertebrate species.
    2. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.
      Title: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apical constriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apical constriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin filament-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical junction complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 6
    Names
    FERM domain-containing protein 163SCII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271054.2 → NP_001257983.1  FERM domain-containing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZM66
      Conserved Domains (3) summary
      smart00295
      Location:20 → 226
      B41; Band 4.1 homologues
      cd13185
      Location:219 → 327
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      cl28922
      Location:15 → 112
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001399291.1 → NP_001386220.1  FERM domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      F1LR29
      Conserved Domains (3) summary
      cd13185
      Location:227 → 335
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      pfam00373
      Location:123 → 234
      FERM_M; FERM central domain
      cl28922
      Location:15 → 120
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001399292.1 → NP_001386221.1  FERM domain-containing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZM66
      Related
      ENSRNOP00000079134.1, ENSRNOT00000100346.2
      Conserved Domains (3) summary
      smart00295
      Location:20 → 226
      B41; Band 4.1 homologues
      cd13185
      Location:219 → 327
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      cl28922
      Location:15 → 112
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      95081958..95155561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261564.1 → XP_063117634.1  FERM domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      F1LR29

    2. XM_063261567.1 → XP_063117637.1  FERM domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZM66

    3. XM_063261565.1 → XP_063117635.1  FERM domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      F1LR29

    4. XM_063261568.1 → XP_063117638.1  FERM domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZM66

    5. XM_063261566.1 → XP_063117636.1  FERM domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      F1LR29
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VII0.2 GenPept UniProtKB/Swiss-Prot:Q8VII0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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