Pygb glycogen phosphorylase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pygbprovided by RGD
Official Full Name: glycogen phosphorylase Bprovided by RGD
Primary source: RGD:3460
See related: EnsemblRapid:ENSRNOG00000007583 AllianceGenome:RGD:3460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GLYPHOA
Summary: Enables several functions, including carbohydrate binding activity; glycogen phosphorylase activity; and identical protein binding activity. Involved in glycogen catabolic process. Located in axon. Orthologous to human PYGB (glycogen phosphorylase B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 915.2), Brain (RPKM 483.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160072141..160118930)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (139611724..139658521)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (146581063..146629504)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thus, glycogen is an active fuel for specific structures in normal activated brain, not simply an emergency fuel depot and flux-generated pyruvate greatly exceeded net accumulation of lactate or net consumption of glycogen during activation. T
Title: A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover.
active and total glycogen phosphorylase were measured histochemically in the entorhinal complex of male Sprague-Dawley rats
Title: Glycogen phosphorylase reactivity in the entorhinal complex in familiar and novel environments: evidence for labile glycogenolytic modules in the rat.
We have demonstrated immunocytochemically the presence of glycogen phosphorylase, brain form in large and small axons of the rat vagus nerve, but not in Schwann cells.
Title: Immunocytochemical analysis of rat vagus nerve by antibodies against glycogen phosphorylase isozymes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127518 (e-PCR)
- UniSTS:210828

RH94711 (e-PCR)
- UniSTS:119958

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables glycogen phosphorylase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables organic cyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycogen phosphorylase, brain form

Names: brain glycogen phosphorylase; phosphorylase, glycogen; phosphorylase, glycogen; brain

NP_037320.1

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013188.1 → NP_037320.1 glycogen phosphorylase, brain form

See identical proteins and their annotated locations for NP_037320.1

Status: VALIDATED

Source sequence(s)

AW535913, CA504871, CB720204, CK357665, CO400919, L10668

UniProtKB/Swiss-Prot

P53534

UniProtKB/TrEMBL

A6KHG6

Related

ENSRNOP00000084107.2, ENSRNOT00000100727.2

Conserved Domains (2) summary

cd04300
Location:29 → 828

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 828

P_ylase; glycogen/starch/alpha-glucan phosphorylases