Hcrtr2 hypocretin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hcrtr2provided by RGD
Official Full Name: hypocretin receptor 2provided by RGD
Primary source: RGD:2788
See related: EnsemblRapid:ENSRNOG00000011251 AllianceGenome:RGD:2788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ox2r; ox2-R; ox-2-R
Summary: Enables orexin receptor activity and peptide hormone binding activity. Involved in feeding behavior and neuropeptide signaling pathway. Predicted to be integral component of plasma membrane. Biomarker of hyperglycemia. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 92.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85870279..85986405, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76989834..77105953, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (83307684..83421612, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blockade of the orexin-2 receptors within the ventral tegmental area facilitates the extinction and prevents the reinstatement of methamphetamine-seeking behavior.
Title: Blockade of the orexin-2 receptors within the ventral tegmental area facilitates the extinction and prevents the reinstatement of methamphetamine-seeking behavior.
Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats.
Title: Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats.
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
Title: Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats.
Title: The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats.
Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus.
Title: Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus.
Orexin A-induced hyperlocomotion is mainly mediated by the activation of the OX2 receptor.
Title: Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats.
Study shows that hippocampal orexin receptor (OXRs) blocking prevented the stress induced social learning and memory deficits. Study identifies hippocampal OXRs as potential candidates capable of preventing acute stress-induced impairments of social novelty and anxiety behavior.
Title: Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits.
The authors concluded that in spontaneously hypertensive rats, orexin neurons in the dorsomedial hypothalamus might be overactive during eating palatable food and may further elicit exaggerated cardiovascular responses via an OX2R-rostral ventrolateral medulla pathway.
Title: Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats.
Results showed that the blockade of Ox1r and Ox2r in the nucleus accumbens (NAc) attenuated the effect of food deprivation (FD) on morphine reinstatement; however, they were more effective in FD condition. Findings indicate that the NAc is a brain area within which orexin has a fundamental role in the effect of stress on morphine-induced reinstatement and the effect of food deprivation- on the reinstatement of morphine.
Title: Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats.
Results suggest that both orexin-1 and -2 receptors in the nucleus accumbens are involved in the development of morphine-induced conditioned place preference. It seems that orexin-1 receptors in this region are more effective in development of drug seeking behaviors in the rats.
Title: Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats.

Submit: New GeneRIF Correction See all GeneRIFs (48)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables orexin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables orexin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables orexin receptor activity	ISO Inferred from Sequence Orthology more info
enables orexin receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian sleep/wake cycle process	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, wakefulness	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, wakefulness	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: orexin receptor type 2

Names: hypocretin (orexin) receptor 2; hypocretin receptor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393819.1 → NP_001380748.1 orexin receptor type 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

Related

ENSRNOP00000111226.1, ENSRNOT00000127511.1

Conserved Domains (1) summary

cd15208
Location:55 → 375

7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_013074.2 → NP_037206.1 orexin receptor type 2 isoform 1

See identical proteins and their annotated locations for NP_037206.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P56719

UniProtKB/TrEMBL

A6I1F5

Related

ENSRNOP00000015824.4, ENSRNOT00000015824.6

Conserved Domains (3) summary

pfam00001
Location:71 → 364

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam03827
Location:386 → 443

Orexin_rec2; Orexin receptor type 2

cl21561
Location:65 → 185

7tm_4; Olfactory receptor