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    Sag S-antigen visual arrestin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25539, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sagprovided by RGD
    Official Full Name
    S-antigen visual arrestinprovided by RGD
    Primary source
    RGD:3619
    See related
    EnsemblRapid:ENSRNOG00000018185 AllianceGenome:RGD:3619
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SAGMR; SANTI
    Summary
    Enables spectrin binding activity. Predicted to be involved in G protein-coupled receptor internalization. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; retinitis pigmentosa; and retinitis pigmentosa 47. Orthologous to human SAG (S-antigen visual arrestin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 5.9), Lung (RPKM 1.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sag in Genome Data Viewer
    Location:
    9q35
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95915640..95956641)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88467797..88508821)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94926901..94972162)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene autophagy related 16-like 1 Neighboring gene small Cajal body-specific RNA 6 like Neighboring gene small Cajal body-specific RNA 6 Neighboring gene diacylglycerol kinase, delta Neighboring gene ubiquitin specific peptidase 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat pineal S-antigen: sequence analysis reveals presence of alpha-transducin homologous sequence. Abe T, et al. FEBS Lett, 1989 Apr 24. PMID 2714438
    2. S-antigen from the rat retina and pineal gland have identical sequences. Abe T, et al. Exp Eye Res, 1990 Jul. PMID 2373176
    3. Differential expression of mRNA and protein encoding retinal and pineal S-antigen during the light/dark cycle. Craft CM, et al. J Neurochem, 1990 Nov. PMID 2213004
    4. The functional cycle of visual arrestins in photoreceptor cells. Gurevich VV, et al. Prog Retin Eye Res, 2011 Nov. PMID 21824527, Free PMC Article
    5. A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese. Fuchs S, et al. Nat Genet, 1995 Jul. PMID 7670478

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prolonged illumination up-regulates retinal arrestin and Guca1a/b: a novel mechanism for light adaptation.
      Title: Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables opsin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables opsin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    S-arrestin
    Names
    48 kDa protein
    S-AG
    S-antigen; retina and pineal gland (arrestin)
    retina and pineal gland (arrestin)
    retinal S-antigen
    rod photoreceptor arrestin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013023.3 → NP_037155.2  S-arrestin

      See identical proteins and their annotated locations for NP_037155.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P15887
      UniProtKB/TrEMBL
      R4GNK4
      Related
      ENSRNOP00000071579.1, ENSRNOT00000085770.3
      Conserved Domains (2) summary
      smart01017
      Location:200 → 361
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:23 → 181
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95915640..95956641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083069.2 → XP_038938997.1  S-arrestin isoform X1

      UniProtKB/Swiss-Prot
      P15887
      UniProtKB/TrEMBL
      R4GNK4
      Conserved Domains (2) summary
      smart01017
      Location:200 → 361
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:23 → 181
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15887.1 GenPept UniProtKB/Swiss-Prot:P15887

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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