Ptgis prostaglandin I2 synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgisprovided by RGD
Official Full Name: prostaglandin I2 synthaseprovided by RGD
Primary source: RGD:3438
See related: EnsemblRapid:ENSRNOG00000008245 AllianceGenome:RGD:3438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PGIS
Summary: Enables prostaglandin-I synthase activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of smooth muscle cell proliferation; and prostaglandin biosynthetic process. Predicted to be located in caveola; endoplasmic reticulum membrane; and nucleus. Used to study cerebral infarction; congestive heart failure; ischemia (multiple); and pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 131.7), Uterus (RPKM 125.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176347589..176383251, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (155928564..155964228, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (163950746..163986129, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that renal reparation of the acute kidney injury due to choline deficiency in some rats is not related with differences in VNTR in the promoter region of the prostacyclin synthase gene.
Title: Variable number tandem repeats in the promoter region of prostacyclin synthase gene in choline deficient rats.
PGIS overexpression apparently protects insulin-producing cells against cytokine toxicity via suppression of endoplasmic reticulum and mitochondrial stress-mediated cell death pathways
Title: Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells.
Prostaglandin D synthase and prostacyclin synthase are present and could be regulated by steroids in the rat uterus during pregnancy. Endometrium could be significant source of PGD(2) and PGI(2) at specific times during pregnancy.
Title: Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids.
Overall, this study demonstrated that engagement of TLR4 with LPS induces production of PGI2 via Akt and generates VEGF through IP receptor.
Title: Activation of toll-like receptor 4 modulates vascular endothelial growth factor synthesis through prostacyclin-IP signaling.
Repeated gene transfer of PGIS into skeletal muscle attenuates monocrotaline-induced pulmonary hypertension and prolongs survival.
Title: Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.
Prostacyclin synthase protects the brain by enhancing PGI2 synthesis and creating a favorable PGI2/TXA2 ratio
Title: Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130734 (e-PCR)
- UniSTS:214018

BI275702 (e-PCR)
- UniSTS:249646

D3Got155 (e-PCR)
- UniSTS:113456

AW529446 (e-PCR)
- UniSTS:261087

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables prostaglandin-I synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-I synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-I synthase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-I synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prostaglandin-I synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-6	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-6	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-6	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostacyclin synthase

Names: hydroperoxy icosatetraenoate dehydratase; prostaglandin I2 (prostacyclin) synthase

NP_113745.1

EC 4.2.1.152

EC 5.3.99.4

XP_038960306.1

EC 4.2.1.152

EC 5.3.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031557.2 → NP_113745.1 prostacyclin synthase

See identical proteins and their annotated locations for NP_113745.1

Status: PROVISIONAL

Source sequence(s)

BC061814

UniProtKB/Swiss-Prot

Q62969

UniProtKB/TrEMBL

A6JXJ3

Related

ENSRNOP00000087709.1, ENSRNOT00000115486.2

Conserved Domains (1) summary

cl12078
Location:28 → 490

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

176347589..176383251 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104378.2 → XP_038960306.1 prostacyclin synthase isoform X1

UniProtKB/TrEMBL

A0A0G2K776, F1LP67

Related

ENSRNOP00000074093.3, ENSRNOT00000082474.3

Conserved Domains (1) summary

cl41757
Location:42 → 483

cytochrome_P450; cytochrome P450 (CYP) superfamily