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    Cpt2 carnitine palmitoyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25413, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cpt2provided by RGD
    Official Full Name
    carnitine palmitoyltransferase 2provided by RGD
    Primary source
    RGD:2398
    See related
    EnsemblRapid:ENSRNOG00000012443 AllianceGenome:RGD:2398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPTII
    Summary
    Enables carnitine O-palmitoyltransferase activity. Involved in fatty acid beta-oxidation and response to fatty acid. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 712.7), Adrenal (RPKM 449.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpt2 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127893450..127911347, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122664677..122682126, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127505646..127523016, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 8 Neighboring gene mago homolog, exon junction complex subunit Neighboring gene CXXC motif containing zinc binding protein Neighboring gene uncharacterized LOC134486962 Neighboring gene zinc finger CCCH-type containing, antiviral 1, pseudogene 9 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity. Akieda K, et al. Biol Pharm Bull, 2024. PMID 38171776
    2. Mitochondrial import and processing of rat liver carnitine palmitoyltransferase II defines the amino terminus of the mature protein. Possibility of differential modification of the rat and human isoforms. Brown NF, et al. J Biol Chem, 1991 Aug 15. PMID 1869564
    3. Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II. Woeltje KF, et al. J Biol Chem, 1990 Jun 25. PMID 2355018
    4. 3-Thia fatty acid treatment, in contrast to eicosapentaenoic acid and starvation, induces gene expression of carnitine palmitoyltransferase-II in rat liver. Madsen L, et al. Lipids, 1999 May. PMID 10380116
    5. A variable myopathy associated with heterozygosity for the R503C mutation in the carnitine palmitoyltransferase II gene. Vladutiu GD, et al. Mol Genet Metab, 2000 Jun. PMID 10873395

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
      Title: GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
    2. Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity.
      Title: Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity.
    3. The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
      Title: The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
    4. Low CPT-II expression might lead to abnormal hepatic lipid accumulation, which should promote the malignant transformation of hepatocytes.
      Title: Mitochondrial carnitine palmitoyl transferase-II inactivity aggravates lipid accumulation in rat hepatocarcinogenesis.
    5. Report interaction between carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase supporting the channeling of acylcarnitines and carnitine at level of the inner mitochondrial membrane.
      Title: Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane.
    6. The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.
      Title: Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog.
    7. crystal structure of carnitine palmitoyltransferase 2
      Title: The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
    8. role of highly conserved C-terminal acidic residues glutamate 487 and glutamate 500 on catalytic activity in liver
      Title: Identification by mutagenesis of a conserved glutamate (Glu487) residue important for catalytic activity in rat liver carnitine palmitoyltransferase II.
    9. surface patch mediates the association of CPT-II with the inner membrane of the mitochondria
      Title: Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnitine O-octanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnitine O-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carnitine O-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carnitine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carnitine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carnitine O-palmitoyltransferase 2, mitochondrial
    Names
    carnitine palmitoyltransferase II
    XP_038965227.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429334.1 → NP_001416263.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NM_001429335.1 → NP_001416264.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NM_001429336.1 → NP_001416265.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZW87

    4. NM_012930.2 → NP_037062.2  carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JYT6, G3V7N5
      Related
      ENSRNOP00000016954.1, ENSRNOT00000016954.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127893450..127911347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109299.2 → XP_038965227.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00755
      Location:49 → 584
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18886.1 GenPept UniProtKB/Swiss-Prot:P18886

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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