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    Cebpe CCAAT/enhancer binding protein epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25410, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cebpeprovided by RGD
    Official Full Name
    CCAAT/enhancer binding protein epsilonprovided by RGD
    Primary source
    RGD:2329
    See related
    EnsemblRapid:ENSRNOG00000014282 AllianceGenome:RGD:2329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CRP1; C/EPBe
    Summary
    Enables DNA binding activity and identical protein binding activity. Involved in cellular response to lipopolysaccharide and myeloid cell differentiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 16.3), Lung (RPKM 5.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cebpe in Genome Data Viewer
    Location:
    15p13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32139716..32141476, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28169711..28171471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33356119..33357517, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene uncharacterized LOC120096982 Neighboring gene solute carrier family 7 member 8 Neighboring gene uncharacterized LOC134482118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. Lekstrom-Himes JA, et al. J Exp Med, 1999 Jun 7. PMID 10359588, Free PMC Article
    2. CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge. Lekstrom-Himes J, et al. Blood, 1999 May 1. PMID 10216107
    3. Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice. Tavor S, et al. Blood, 2002 Mar 1. PMID 11861297
    4. Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon. Gombart AF, et al. Blood, 2001 May 1. PMID 11313242
    5. Molecular studies of prion diseases. Safar J, et al. Prog Brain Res, 1998. PMID 9932423

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myeloid cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myeloid cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCAAT/enhancer-binding protein epsilon
    Names
    CCAAT/enhancer binding protein (C/EBP), epsilon
    CCAAT/enhancer binding protein , epsilon
    c/EBP epsilon
    c/EBP-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017095.2 → NP_058791.1  CCAAT/enhancer-binding protein epsilon

      See identical proteins and their annotated locations for NP_058791.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P56261
      UniProtKB/TrEMBL
      A6KGV9
      Related
      ENSRNOP00000019154.1, ENSRNOT00000019155.5
      Conserved Domains (1) summary
      cd14715
      Location:202 → 262
      bZIP_CEBPE; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein epsilon (CEBPE): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32139716..32141476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56261.2 GenPept UniProtKB/Swiss-Prot:P56261

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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