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    Cd80 Cd80 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25408, updated on 2-Nov-2024

    Summary

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    Symbol
    Cd80provided by RGD
    Full Name
    Cd80 moleculeprovided by RGD
    Primary source
    RGD:2314
    See related
    EnsemblRapid:ENSRNOG00000001527 AllianceGenome:RGD:2314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B7-1
    Summary
    Predicted to enable receptor ligand activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia/lymphoma; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 25.4), Thymus (RPKM 23.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd80 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75760073..75798978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62254543..62293414, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64815201..64855293, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 1 Neighboring gene uncharacterized LOC103693581 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Pang S, et al. Eur J Immunol, 2009 Oct. PMID 19658094
    2. Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment. Page K, et al. J Innate Immun, 2011. PMID 21051864, Free PMC Article
    3. Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice. Tobita K, et al. Anim Sci J, 2010 Dec. PMID 21108691
    4. Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis. Lee-Chang C, et al. Clin Immunol, 2011 Apr. PMID 21310664
    5. A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells. Zhang F, et al. Clin Exp Immunol, 2011 May. PMID 21352203, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.
      Title: Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.
    2. Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.
      Title: Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.
    3. ETRA antagonist restores podocyte foot process effacement as well as the aberrant expression of TLR-3, nuclear factor-kappaB (NF-kappaB), and CD80 in puromycin aminonucleoside-injured kidneys
      Title: Antiproteinuric effect of an endothelin-1 receptor antagonist in puromycin aminonucleoside-induced nephrosis in rat.
    4. Selective expression of B7-1 (CD80) is important and may serve as a guide for future therapies aimed at transplant tolerance.
      Title: HLA-G-treated tolerogenic dendritic cells induce tolerogenic potential by increasing expression of B7-1 (CD80) molecules.
    5. Blocking expression of B7.1 in donor spleens by antisense gene therapy represents a potential alloantigen-specific immunosuppressive strategy to inhibit acute rejection against splenic allografts.
      Title: Gene transfer of antisense B7.1 attenuates acute rejection against splenic allografts in rats.
    6. Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of rimary glomerular disease.
      Title: Early changes in gene expression that influence the course of primary glomerular disease.
    7. B7.1 and B7.2 are expressed in the eye at different times during experimental autoimmune anterior uveitis. Both B7 molecules are required for the induction of EAAU, although they probably have different roles.
      Title: Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU).
    8. CTLA4Ig gene therapy is a successful strategy for the prevention of allogeneic graft rejection in corneal transplantation. Our work has further elucidated the mechanisms of corneal allograft rejection which may lead to novel therapeutic strategies.
      Title: Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival.
    9. Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.
      Title: Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.
    10. an inducible diabetes model in transgenic mice based on rat insulin promotor (RIP)-driven expression of CD80 (B7-1) on pancreatic beta cells.
      Title: Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    CD80 antigen
    CD80-like
    Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418663.2 → NP_001405592.1  T-lymphocyte activation antigen CD80 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IR66
      Related
      ENSRNOP00000002089.6, ENSRNOT00000002089.6

    2. NM_012926.2 → NP_037058.2  T-lymphocyte activation antigen CD80 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IR66, O35187
      Conserved Domains (3) summary
      cd00096
      Location:41 → 46
      Ig; Ig strand A [structural motif]
      cd16083
      Location:147 → 237
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:40 → 144
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      75760073..75798978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088035.2 → XP_038943963.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      G3V671, O35187
      Conserved Domains (3) summary
      cd00096
      Location:41 → 46
      Ig; Ig strand A [structural motif]
      cd16083
      Location:147 → 237
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:40 → 144
      Ig; Immunoglobulin domain

    2. XM_039088036.2 → XP_038943964.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      G3V671, O35187
      Related
      ENSRNOP00000110921.1, ENSRNOT00000172449.1
      Conserved Domains (3) summary
      cd00096
      Location:41 → 46
      Ig; Ig strand A [structural motif]
      cd16083
      Location:147 → 237
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:40 → 144
      Ig; Immunoglobulin domain

    3. XM_063270308.1 → XP_063126378.1  T-lymphocyte activation antigen CD80 isoform X2

      UniProtKB/TrEMBL
      A6IR66

    4. XM_063270307.1 → XP_063126377.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      G3V671

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001418662.1: Suppressed sequence

      Description
      NM_001418662.1: This RefSeq was removed because it is redundant with another Refseq.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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