Cacna1a calcium voltage-gated channel subunit alpha1 A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna1aprovided by RGD
Official Full Name: calcium voltage-gated channel subunit alpha1 Aprovided by RGD
Primary source: RGD:2244
See related: EnsemblRapid:ENSRNOG00000052707 AllianceGenome:RGD:2244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BccA1; rbA-1; Cav2.1
Summary: Enables calmodulin binding activity and high voltage-gated calcium channel activity. Involved in calcium ion import; chemical synaptic transmission; and regulation of voltage-gated calcium channel activity. Located in perikaryon. Part of voltage-gated calcium channel complex. Is active in calyx of Held and presynaptic active zone membrane. Used to study childhood absence epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 93.8), Kidney (RPKM 16.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40425560..40724810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23520741..23819971, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25453236..25749550)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Transcription Factor, alpha1ACT, Acts Through a MicroRNA Network to Regulate Neurogenesis and Cell Death During Neonatal Cerebellar Development.
Title: The Transcription Factor, α1ACT, Acts Through a MicroRNA Network to Regulate Neurogenesis and Cell Death During Neonatal Cerebellar Development.
Scn1a and Cacna1a mutations mutually alter their original phenotypes in rats.
Title: Scn1a and Cacna1a mutations mutually alter their original phenotypes in rats.
Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy.
Title: Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy.
Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy.
Title: Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl(3)-induced epilepsy.
Protein Kinase CK2 Controls CaV2.1-Dependent Calcium Currents and Insulin Release in Pancreatic beta-Cells.
Title: Protein Kinase CK2 Controls Ca(V)2.1-Dependent Calcium Currents and Insulin Release in Pancreatic β-Cells.
alpha1ACT, as a transcription factor and secondary protein of CACNA1A mRNA, drives dynamic gene expression networks within cerebellar Purkinje cells and is indispensable for neonatal survival.
Title: α1ACT Is Essential for Survival and Early Cerebellar Programming in a Critical Neonatal Window.
exon 47-related alternative splicing of CaV2.1 channels controls synapse-specific release properties at the level of channel mobility-dependent coupling between voltage-gated calcium channels and synaptic vesicles
Title: Transient Confinement of Ca(V)2.1 Ca(2+)-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
L-type Ca(2+) channels are involved in IFN-gamma-induced signaling in rat ventricular cardiomyocytes.
Title: L-type Ca(2+) channels' involvement in IFN-γ-induced signaling in rat ventricular cardiomyocytes.
Conclude that expression of the Cacna1a mRNA increased before the onset of alcohol withdrawal syndrome susceptibility, suggesting that altered CaV2.1 channel expression may play a role in AWS pathogenesis.
Title: Alcohol withdrawal upregulates mRNA encoding for Ca(V)2.1-α1 subunit in the rat inferior colliculus.
postulate that the N-terminus of the truncated channel plays an essential part in its interaction with the full-length CaV2.1, which prevents the correct folding of the wild-type channel
Title: A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143033 (e-PCR)
- UniSTS:232280

Cacna1a (e-PCR), detects polymorphism
- UniSTS:141208

RH137733 (e-PCR)
- UniSTS:219820

RH140588 (e-PCR)
- UniSTS:222657

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables high voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar Purkinje cell layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar molecular layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum maturation	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within musculoskeletal movement, spinal reflex action	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within receptor clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of acetylcholine secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hormone levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of sulfur amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vestibular nucleus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in somatodendritic compartment	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent P/Q-type calcium channel subunit alpha-1A

Names: BI; RBA-I; brain calcium channel 1; brain calcium channel I; brain class A; calcium channel alpha 1A; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; calcium channel, voltage-dependent, alpha 1A subunit; voltage-gated calcium channel subunit alpha Cav2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012918.6 → NP_037050.3 voltage-dependent P/Q-type calcium channel subunit alpha-1A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A0G2JXK1

Related

ENSRNOP00000096924.2, ENSRNOT00000106526.2

Conserved Domains (5) summary

PHA03247
Location:790 → 1171

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1945 → 2349

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1516 → 1773

Ion_trans; Ion transport protein

pfam08763
Location:1846 → 1919

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1782 → 1835

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40425560..40724810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277790.1 → XP_063133860.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3
XM_063277793.1 → XP_063133863.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X6
XM_039097487.2 → XP_038953415.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2

UniProtKB/TrEMBL

A0A8I5ZPG4

Related

ENSRNOP00000070304.3, ENSRNOT00000083448.3

Conserved Domains (5) summary

PHA03247
Location:878 → 1259

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2033 → 2437

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1604 → 1861

Ion_trans; Ion transport protein

pfam08763
Location:1934 → 2007

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1870 → 1923

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_063277792.1 → XP_063133862.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5

Related

ENSRNOP00000080121.1, ENSRNOT00000102295.2
XM_063277791.1 → XP_063133861.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X4
XM_063277789.1 → XP_063133859.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1
XM_063277795.1 → XP_063133865.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X8
XM_063277794.1 → XP_063133864.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7
XM_063277798.1 → XP_063133868.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X11
XM_063277797.1 → XP_063133867.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X10
XM_063277799.1 → XP_063133869.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X11
XM_063277796.1 → XP_063133866.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X9