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    EIF4E1B eukaryotic translation initiation factor 4E family member 1B [ Homo sapiens (human) ]

    Gene ID: 253314, updated on 28-Oct-2024

    Summary

    Official Symbol
    EIF4E1Bprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E family member 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:33179
    See related
    Ensembl:ENSG00000175766 AllianceGenome:HGNC:33179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See EIF4E1B in Genome Data Viewer
    Location:
    5q35.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176630675..176646644)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177177255..177193232)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176057676..176073645)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cadherin related family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16659 Neighboring gene G protein regulated inducer of neurite outgrowth 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16661 Neighboring gene Sharpr-MPRA regulatory region 11151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16663 Neighboring gene synuclein beta Neighboring gene microRNA 4281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176070445-176071086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176071087-176071726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176072308-176072818 Neighboring gene Sharpr-MPRA regulatory region 4950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176075745-176076614 Neighboring gene VISTA enhancer hs2007 Neighboring gene tetraspanin 17 Neighboring gene uncharacterized LOC124901144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176087757-176088480 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176093385-176093611

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ36951

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E type 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099408.2NP_001092878.1  eukaryotic translation initiation factor 4E type 1B

      See identical proteins and their annotated locations for NP_001092878.1

      Status: VALIDATED

      Source sequence(s)
      AC091934, AK094270, BM709255, DA689940, DR008159, DR731203
      Consensus CDS
      CCDS47345.1
      UniProtKB/Swiss-Prot
      A6NMX2
      Related
      ENSP00000323714.6, ENST00000318682.11
      Conserved Domains (1) summary
      pfam01652
      Location:63222
      IF4E; Eukaryotic initiation factor 4E
    2. NM_001375362.1NP_001362291.1  eukaryotic translation initiation factor 4E type 1B

      Status: VALIDATED

      Source sequence(s)
      AC091934
      Consensus CDS
      CCDS47345.1
      UniProtKB/Swiss-Prot
      A6NMX2
      Related
      ENSP00000497422.1, ENST00000647833.1
      Conserved Domains (1) summary
      pfam01652
      Location:63222
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      176630675..176646644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      177177255..177193232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)