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    Abcc2 ATP binding cassette subfamily C member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25303, updated on 28-Oct-2024

    Summary

    Official Symbol
    Abcc2provided by RGD
    Official Full Name
    ATP binding cassette subfamily C member 2provided by RGD
    Primary source
    RGD:2366
    See related
    EnsemblRapid:ENSRNOG00000046727 AllianceGenome:RGD:2366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mrp; Mrp2; cMRP; Cmoat
    Summary
    Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward (RPKM 1630.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcc2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252613875..252672459)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242664657..242723239)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263554426..263612556)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cutC copper transporter Neighboring gene cystatin B, pseudogene 1 Neighboring gene dynamin binding protein Neighboring gene uncharacterized LOC134484058 Neighboring gene casein kinase 2 alpha 1, pseudogene 2 Neighboring gene carboxypeptidase N subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type glutathione S-conjugate transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type glutathione S-conjugate transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ABC-type glutathione S-conjugate transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables bilirubin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bilirubin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables bilirubin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in benzylpenicillin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bile acid and bile salt transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bilirubin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bilirubin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bilirubin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canalicular bile acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in detoxification of mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intracellular chloride ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukotriene transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukotriene transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukotriene transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mercury ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organic anion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organic anion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in prostaglandin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to antineoplastic agent IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucagon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thyroid hormone transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transepithelial transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transepithelial transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic export from cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic export from cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in xenobiotic transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular canaliculus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette sub-family C member 2
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 2
    ATP-binding cassette, subfamily C (CFTR/MRP), member 2
    cMrp2/cMoat canalicular apical conjugate export pump
    calicular multispecific organic anion transporter
    canalicular multidrug resistance protein
    canalicular multispecific organic anion transporter 1
    multidrug resistance-associated protein 2
    NP_036965.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012833.2NP_036965.1  ATP-binding cassette sub-family C member 2

      See identical proteins and their annotated locations for NP_036965.1

      Status: REVIEWED

      Source sequence(s)
      JAXUCZ010000001, L49379, X96393
      UniProtKB/Swiss-Prot
      Q63120, Q63145
      UniProtKB/TrEMBL
      A0A8I6G7X8
      Related
      ENSRNOP00000064799.1, ENSRNOT00000070861.4
      Conserved Domains (4) summary
      TIGR00957
      Location:71533
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:12941514
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:633834
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:9791245
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      252613875..252672459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)