Il13ra1 interleukin 13 receptor subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il13ra1provided by RGD
Official Full Name: interleukin 13 receptor subunit alpha 1provided by RGD
Primary source: RGD:628741
See related: EnsemblRapid:ENSRNOG00000013170 AllianceGenome:RGD:628741
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables interleukin-13 receptor activity. Involved in positive regulation of B cell proliferation and positive regulation of immunoglobulin production. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human IL13RA1 (interleukin 13 receptor subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 464.4), Lung (RPKM 287.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (120213670..120294777)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (115348822..115408682)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (122724081..122783801)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-13 receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in interleukin-13-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-13 receptor subunit alpha-1

Names: interleukin 13 receptor, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145789.3 → NP_665732.2 interleukin-13 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_665732.2

Status: VALIDATED

Source sequence(s)

BC093615, JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2JZB2, Q561K3, Q8VHC2

Conserved Domains (2) summary

cd00063
Location:225 → 335

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:127 → 221

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding