U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FUT6 fucosyltransferase 6 [ Homo sapiens (human) ]

    Gene ID: 2528, updated on 2-Nov-2024

    Summary

    Official Symbol
    FUT6provided by HGNC
    Official Full Name
    fucosyltransferase 6provided by HGNC
    Primary source
    HGNC:HGNC:4017
    See related
    Ensembl:ENSG00000156413 MIM:136836; AllianceGenome:HGNC:4017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FT1A; FCT3A; Fuc-TVI; FucT-VI
    Summary
    The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in kidney (RPKM 17.3), esophagus (RPKM 12.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FUT6 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5830408..5839702, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5817873..5827142, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5830419..5839713, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13816 Neighboring gene dihydrouridine synthase 3 like Neighboring gene Sharpr-MPRA regulatory region 11822 Neighboring gene neurturin Neighboring gene Sharpr-MPRA regulatory region 2060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5827746-5828434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9936 Neighboring gene uncharacterized LOC101928844 Neighboring gene fucosyltransferase 3 (Lewis blood group) Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5855126-5855513 Neighboring gene Sharpr-MPRA regulatory region 2774 Neighboring gene fucosyltransferase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Fucosyltransferase 6 deficiency
    MedGen: C3151219 OMIM: 613852 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
    EBI GWAS Catalog
    Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
    EBI GWAS Catalog
    Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
    EBI GWAS Catalog

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • FLJ40754

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of methylosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
    Names
    alpha-(1,3)-fucosyltransferase 6
    fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
    fucosyltransferase VI
    galactoside 3-L-fucosyltransferase
    NP_000141.1
    NP_001035791.1
    NP_001356431.1
    NP_001356433.1
    NP_001356434.1
    NP_001368884.1
    NP_001368885.1
    NP_001368886.1
    NP_001368887.1
    NP_001368888.1
    XP_047294509.1
    XP_047294510.1
    XP_047294511.1
    XP_047294512.1
    XP_047294513.1
    XP_047294514.1
    XP_047294515.1
    XP_047294516.1
    XP_047294517.1
    XP_054176405.1
    XP_054176406.1
    XP_054176407.1
    XP_054176408.1
    XP_054176409.1
    XP_054176410.1
    XP_054176411.1
    XP_054176412.1
    XP_054176413.1
    XP_054176414.1
    XP_054176415.1
    XP_054176416.1
    XP_054176417.1
    XP_054176418.1
    XP_054176419.1
    XP_054189233.1
    XP_054189234.1
    XP_054189235.1
    XP_054189236.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007505.1 RefSeqGene

      Range
      5030..14324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000150.4NP_000141.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      See identical proteins and their annotated locations for NP_000141.1

      Status: REVIEWED

      Source sequence(s)
      AC024592
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Related
      ENSP00000313398.4, ENST00000318336.10
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    2. NM_001040701.2NP_001035791.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      See identical proteins and their annotated locations for NP_001035791.1

      Status: REVIEWED

      Source sequence(s)
      AC024592
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Related
      ENSP00000286955.5, ENST00000286955.5
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    3. NM_001369502.1NP_001356431.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC024592, AF131211, DA426469
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Related
      ENSP00000432954.1, ENST00000527106.5
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    4. NM_001369504.1NP_001356433.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC024592, AF131211, AK098073, DA426469, DA761223
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    5. NM_001369505.1NP_001356434.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC024592, AF131211, DA426469, DA761273
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    6. NM_001381955.1NP_001368884.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC024592
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    7. NM_001381956.1NP_001368885.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC024592
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
      UniProtKB/TrEMBL
      B2R7V3
      Conserved Domains (2) summary
      pfam00852
      Location:188351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    8. NM_001381957.1NP_001368886.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC024592
      UniProtKB/TrEMBL
      B2R7V3
      Related
      ENSP00000466016.1, ENST00000592563.1
      Conserved Domains (2) summary
      pfam00852
      Location:188350
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    9. NM_001381958.1NP_001368887.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC024592
      UniProtKB/TrEMBL
      B2R7V3
      Conserved Domains (2) summary
      pfam00852
      Location:188350
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    10. NM_001381959.1NP_001368888.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC024592
      UniProtKB/TrEMBL
      B2R7V3
      Conserved Domains (2) summary
      pfam00852
      Location:188350
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      5830408..5839702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438560.1XP_047294516.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    2. XM_047438557.1XP_047294513.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    3. XM_047438556.1XP_047294512.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    4. XM_047438553.1XP_047294509.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    5. XM_047438558.1XP_047294514.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    6. XM_047438561.1XP_047294517.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    7. XM_047438555.1XP_047294511.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    8. XM_047438554.1XP_047294510.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    9. XM_047438559.1XP_047294515.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791810.1 Reference GRCh38.p14 PATCHES

      Range
      4009..13279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333258.1XP_054189233.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    2. XM_054333261.1XP_054189236.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    3. XM_054333260.1XP_054189235.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    4. XM_054333259.1XP_054189234.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      5817873..5827142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320442.1XP_054176417.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    2. XM_054320438.1XP_054176413.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    3. XM_054320430.1XP_054176405.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    4. XM_054320433.1XP_054176408.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    5. XM_054320431.1XP_054176406.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    6. XM_054320440.1XP_054176415.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    7. XM_054320443.1XP_054176418.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    8. XM_054320436.1XP_054176411.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    9. XM_054320444.1XP_054176419.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    10. XM_054320432.1XP_054176407.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    11. XM_054320435.1XP_054176410.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    12. XM_054320434.1XP_054176409.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    13. XM_054320441.1XP_054176416.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X2

    14. XM_054320437.1XP_054176412.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8
    15. XM_054320439.1XP_054176414.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

      UniProtKB/Swiss-Prot
      A6NEX0, D6W637, P51993, Q9UND8