Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dyrk1aprovided by RGD
Official Full Name: dual specificity tyrosine phosphorylation regulated kinase 1Aprovided by RGD
Primary source: RGD:2528
See related: EnsemblRapid:ENSRNOG00000001662 AllianceGenome:RGD:2528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dyrk; PSK47
Summary: Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including protein phosphorylation; regulation of RNA splicing; and regulation of cardiac muscle tissue growth. Located in nuclear speck. Used to study congestive heart failure and dilated cardiomyopathy. Biomarker of hyperhomocysteinemia; myocardial infarction; and renovascular hypertension. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 179.0), Muscle (RPKM 155.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (47360824..47479033)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (33890706..34009420)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (34858339..34958733)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of DYRK1a in myocardial ischemia-reperfusion injury by regulating ferroptosis of cardiomyocytes.
Title: Mechanism of DYRK1a in myocardial ischemia-reperfusion injury by regulating ferroptosis of cardiomyocytes.
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Title: The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Dyrk1A involved in the regulation of alternative splicing of tau exon 10 in vivo. Overexpression of Dyrk1A in neonatal Ts65Dn mouse brains suppressed tau exon 10 inclusion, leading to an increase of 3R-tau/4R-tau ratio. Inhibition of Dyrk1A promotes endogenous tau exon 10 inclusion in cultured cells and in neonatal rat brain.
Title: Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice.
Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.
Title: Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling.
Enhanced activation of Dyrk1A-ASF-CaMKIIdelta signaling pathway may underlie the mechanisms of HF after MI, and Dyrk1A inhibition may contribute to inactivation of this pathway and thereby retard the progression of MI-induced HF.
Title: Involvement of the dual-specificity tyrosine phosphorylation-regulated kinase 1A-alternative splicing factor-calcium/calmodulin-dependent protein kinase IIδ signaling pathway in myocardial infarction-induced heart failure of rats.
calcineurin/NFAT pathway mediates the upregulation of PAI-1 by NGF
Title: NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect.
A model of DYRK autoactivation has been proposed in which tyrosine autophosphorylation in the activation loop stabilizes a conformation of the catalytic domain with enhanced serine/threonine kinase activity without disabling tyrosine phosphorylation.
Title: Mechanism of dual specificity kinase activity of DYRK1A.
Dyrk1A negatively regulates actin filament assembly by phosphorylating N-WASP, which ultimately promotes the intramolecular interaction of its GTPase-binding and verprolin, cofilin and acidic domains
Title: Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP.
Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion.
Title: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.
Decreased expression of Dyrk1a in rat heart leads to cardiomyocyte hypertrophy in hyperhomocysteinemic rats.
Title: Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dyrk1a (e-PCR), detects polymorphism
- UniSTS:536448

D11Wox11 (e-PCR)
- UniSTS:518811

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle hypertrophy	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA methylation-dependent heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-threonine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deacetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neurofilament	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 1A

Names: Dual Specificity Yak1-related kinase; MNBH; RP86; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; protein kinase minibrain homolog

NP_036923.1

EC 2.7.11.23

EC 2.7.12.1

XP_038943954.1

EC 2.7.11.23

EC 2.7.12.1

XP_038943955.1

EC 2.7.11.23

EC 2.7.12.1

XP_038943956.1

EC 2.7.11.23

EC 2.7.12.1

XP_038943959.1

EC 2.7.11.23

EC 2.7.12.1

XP_038943960.1

EC 2.7.11.23

EC 2.7.12.1

XP_063126374.1

EC 2.7.11.23

EC 2.7.12.1

XP_063126375.1

EC 2.7.11.23

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012791.3 → NP_036923.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A

See identical proteins and their annotated locations for NP_036923.1

Status: REVIEWED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q63470

UniProtKB/TrEMBL

A0A8I5ZY45, A6KPV9

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

47360824..47479033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088026.2 → XP_038943954.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

UniProtKB/Swiss-Prot

Q63470

UniProtKB/TrEMBL

A0A8I5ZY45, A6KPV9

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_039088031.2 → XP_038943959.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

UniProtKB/TrEMBL

A0A8I5ZY45, A0A8I6GL29

Related

ENSRNOP00000096172.1, ENSRNOT00000114109.2

Conserved Domains (1) summary

cd14226
Location:139 → 475

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_063270304.1 → XP_063126374.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

UniProtKB/Swiss-Prot

Q63470

UniProtKB/TrEMBL

A6KPV9
XM_039088027.2 → XP_038943955.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

UniProtKB/Swiss-Prot

Q63470

UniProtKB/TrEMBL

A0A8I5ZY45, A6KPV9

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_039088028.2 → XP_038943956.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

UniProtKB/Swiss-Prot

Q63470

UniProtKB/TrEMBL

A0A8I5ZY45, A6KPV9

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_063270305.1 → XP_063126375.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2
XM_039088032.2 → XP_038943960.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZY45

Related

ENSRNOP00000042446.6, ENSRNOT00000050342.7

Conserved Domains (1) summary

cd14226
Location:119 → 455

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1