Casp1 caspase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Casp1provided by RGD
Official Full Name: caspase 1provided by RGD
Primary source: RGD:2274
See related: EnsemblRapid:ENSRNOG00000007372 AllianceGenome:RGD:2274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ice; p45; Il1bc
Summary: Enables scaffold protein binding activity. Involved in several processes, including microglial cell activation; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Part of protein-containing complex. Used to study acute kidney failure and visual epilepsy. Biomarker of myocardial infarction. Orthologous to human CASP1 (caspase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 365.4), Lung (RPKM 223.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (10746338..10882295)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (2587812..2597403)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (2605743..2614637)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.
Title: Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.
Exosome miR-223-3p in the bone marrow-derived mesenchymal stem cells alleviates the inflammation and airway remodeling through NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway.
Title: Exosome miR-223-3p in the bone marrow-derived mesenchymal stem cells alleviates the inflammation and airway remodeling through NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway.
Intrauterine exposure to oxidative stress induces caspase-1-dependent enteric nerve cell pyroptosis.
Title: Intrauterine exposure to oxidative stress induces caspase-1-dependent enteric nerve cell pyroptosis.
Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling.
Title: Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling.
Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury.
Title: Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury.
Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons.
Title: Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons.
cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection.
Title: cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection.
Our data showed there are significant correlations between some sperm parameters and inflammasome gene expression. Casp-1 expression negatively correlated with sperm count and progressive motility.
Title: The Correlation of Gene Expression of Inflammasome Indicators and Impaired Fertility in Rat Model of Spinal Cord Injury: A Time Course Study.
Emodin alleviated pancreatic and intestinal mucosa injury in experimental severe acute pancreatitis. Its mechanism may partly be mediated by the inhibition of caspase-1 and its downstream inflammatory cytokines, including IL-1beta and IL-18.
Title: Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition.
neuronal injury/traumatic brain injury (TBI) can induce a high influx of Ca(2+) to the cells that cause neuroinflammation and cell death by activating caspase-1, IL-1beta, and intrinsic apoptotic pathways.
Title: High Ca(2+) Influx During Traumatic Brain Injury Leads to Caspase-1-Dependent Neuroinflammation and Cell Death.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141870 (e-PCR)
- UniSTS:223862

Casp1 (e-PCR), detects polymorphism
- UniSTS:259198

Casp1 (e-PCR), detects polymorphism
- UniSTS:141228

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables caspase binding	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in AIM2 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cytokine precursor processing	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane hyperpolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 alpha production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in programmed necrotic cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AIM2 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AIM2 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of AIM2 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of IPAF inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IPAF inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of IPAF inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of IPAF inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NLRP1 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP1 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NLRP3 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NLRP3 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP3 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protease inhibitor complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-1

Names: IL-1 beta-converting enzyme; Interleukin 1beta converting enzyme; interleukin 1, beta, convertase; interleukin-1 beta-converting enzyme

NP_036894.3

EC 3.4.22.36

XP_063121014.1

EC 3.4.22.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012762.3 → NP_036894.3 caspase-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P43527

UniProtKB/TrEMBL

A6KQJ8, F1LQZ4

Related

ENSRNOP00000086752.2, ENSRNOT00000098719.2

Conserved Domains (2) summary

smart00115
Location:152 → 400

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08325
Location:6 → 87

CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins