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    Plagl1 PLAG1 like zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25157, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plagl1provided by RGD
    Official Full Name
    PLAG1 like zinc finger 1provided by RGD
    Primary source
    RGD:3014
    See related
    EnsemblRapid:ENSRNOG00000025587 AllianceGenome:RGD:3014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lot1; Zac1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and skeletal muscle cell differentiation. Predicted to be located in Golgi apparatus and nuclear body. Orthologous to human PLAGL1 (PLAG1 like zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 93.1), Kidney (RPKM 43.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plagl1 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9297066..9337394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7477295..7517229)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7219587..7270169)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 5 Neighboring gene ferritin light chain 1, pseudogene 4 Neighboring gene uncharacterized LOC134484946 Neighboring gene keratin-associated protein 5-1-like Neighboring gene zinc finger, C2HC-type containing 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of Zac1 gene expression in rat white adipose tissue by androgens. Mirowska A, et al. J Steroid Biochem Mol Biol, 2014 Mar. PMID 24316431
    2. Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells. Contestabile A, et al. J Biol Chem, 2005 Sep 30. PMID 16061485
    3. Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation. Fila T, et al. J Biol Chem, 2009 May 29. PMID 19346254, Free PMC Article
    4. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Abdollahi A, et al. Cancer Res, 1997 May 15. PMID 9158001
    5. Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors. Abdollahi A, et al. Oncogene, 1997 Apr 24. PMID 9150364

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zac1 is strongly expressed in white adipose tissue of adult rats,compared to other organs/tissues. Androgens could play an important role in down-regulation of the ZAC1 mRNA and protein levels in rats.
      Title: Down-regulation of Zac1 gene expression in rat white adipose tissue by androgens.
    2. ZAC1 is a novel and previously unknown regulator of cardiomyocyte Glut4 expression and glucose uptake; MEF2 is a regulator of ZAC1 expression in response to induction of hypertrophy
      Title: Regulation of cardiomyocyte Glut4 expression by ZAC1.
    3. Lot1 is a key element of the PACAP/cAMP pathway that negatively regulates neuronal precursor proliferation.
      Title: Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation.
    4. Cyclic AMP-mediated regulation of Lot1 expression is described in cerebellar granule cells.
      Title: Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein PLAGL1
    Names
    Lost on transformation 1
    pleiomorphic adenoma gene-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012760.4 → NP_036892.1  zinc finger protein PLAGL1

      See identical proteins and their annotated locations for NP_036892.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      P70616
      Conserved Domains (2) summary
      sd00017
      Location:6 → 26
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:49 → 73
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      9297066..9337394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281345.1 → XP_063137415.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    2. XM_063281356.1 → XP_063137426.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    3. XM_063281350.1 → XP_063137420.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    4. XM_063281358.1 → XP_063137428.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    5. XM_063281361.1 → XP_063137431.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    6. XM_063281365.1 → XP_063137435.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    7. XM_063281340.1 → XP_063137410.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616

    8. XM_063281341.1 → XP_063137411.1  zinc finger protein PLAGL1 isoform X1

      UniProtKB/TrEMBL
      P70616
      Related
      ENSRNOP00000030918.2, ENSRNOT00000030329.5
    Nucleotide Protein Strain
    Heading Accession and Version

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