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    Rbp1 retinol binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25056, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rbp1provided by RGD
    Official Full Name
    retinol binding protein 1provided by RGD
    Primary source
    RGD:3543
    See related
    AllianceGenome:RGD:3543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables retinol binding activity. Involved in response to benzoic acid; response to retinoic acid; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 917.6), Kidney (RPKM 594.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbp1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (107904589..107926109)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99025218..99046740)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (106449321..106470842)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene calsyntenin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene nicotinamide nucleotide adenylyltransferase 3 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 8 Neighboring gene retinol binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins. Levin MS, et al. J Biol Chem, 1987 May 25. PMID 3584109
    2. [The role of cellular retinol-binding protein-1 on pulmonary structural remodeling after rat myocardial infarction]. Li L, et al. Zhonghua Yi Xue Za Zhi, 2012 Jul 10. PMID 22944241
    3. The primary structure of rat liver cellular retinol-binding protein. Sundelin J, et al. J Biol Chem, 1985 May 25. PMID 4039728
    4. Cellular retinol-binding protein. Quantitation and distribution. Eriksson U, et al. J Biol Chem, 1984 Nov 10. PMID 6541654
    5. Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange. Careri M, et al. Rapid Commun Mass Spectrom, 2006. PMID 16755609

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Retinal proteomic evaluation of rats following streptozotocininjection using shotgun proteomics.
      Title: Retinal proteomic evaluation of rats following streptozotocin‑injection using shotgun proteomics.
    2. CRBP1 contributes to pulmonary structural remodeling after myocardial infarction.
      Title: [The role of cellular retinol-binding protein-1 on pulmonary structural remodeling after rat myocardial infarction].
    3. a potential role of CRBP1 in the regulation of beta-catenin turnover which can greatly affect the process of osteogenesis and adipogenesis of mesenchymal stem cells
      Title: Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRα-induced β-catenin degradation.
    4. As the convoluted proximal tubular epithelial cells dedifferentiate during fibrosis, CRBP-I expression decreases in adriamycin-induced fibrotic rat kidney.
      Title: CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis.
    5. analysis of conformational flexibility of rat cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II)
      Title: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.
    6. Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution
      Title: Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution.
    7. CRBP1 has a role in vitamin A metabolism and its absence may play a role in ovarian cancer oncogenesis
      Title: Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer.
    8. differences in conformational flexibility between the ligand-free and ligand-bound forms of cellular retinol-binding protein type I
      Title: Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to benzoic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to retinoic acid HEP PubMed 
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to vitamin A ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vitamin A metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vitamin A metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinol-binding protein 1
    Names
    CRBP
    CRBP-I
    cellular retinol-binding protein I
    retinol binding protein 1, cellular
    NP_036865.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012733.5 → NP_036865.1  retinol-binding protein 1

      See identical proteins and their annotated locations for NP_036865.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P02696
      Conserved Domains (1) summary
      cd19462
      Location:4 → 134
      CRBP1; cellular retinol-binding protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      107904589..107926109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02696.2 GenPept UniProtKB/Swiss-Prot:P02696

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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