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Fgfr2 fibroblast growth factor receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25022, updated on 14-Nov-2024

Summary

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Official Symbol: Fgfr2provided by RGD
Official Full Name: fibroblast growth factor receptor 2provided by RGD
Primary source: RGD:2611
See related: EnsemblRapid:ENSRNOG00000016374 AllianceGenome:RGD:2611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KGFR
Summary: Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in several processes, including cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and positive regulation of vascular associated smooth muscle cell proliferation. Located in cell surface. Used to study prostate cancer and retinitis pigmentosa. Biomarker of essential hypertension; hypospadias; portal hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 150.3), Lung (RPKM 131.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Fgfr2 in Genome Data Viewer

Location:: 1q37

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (194175703..194280914, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (184745418..184850655, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (200590951..200696946, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of lncRNA TUG1 alleviates diabetic retinal vascular dysfunction through regulating miR-524-5p/FGFR2.
Title: Knockdown of lncRNA TUG1 alleviates diabetic retinal vascular dysfunction through regulating miR-524-5p/FGFR2.
miR2175p regulates myogenesis in skeletal muscle stem cells by targeting FGFR2.
Title: miR‑217‑5p regulates myogenesis in skeletal muscle stem cells by targeting FGFR2.
Suggest the potential involvement of altered Fgf10/Fgfr2/AR signaling in pathogenesis of anorectal malformations induced by di-n-butyl phthalate.
Title: Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP.
Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.
Title: Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.
Upregulation of FGFR2 and FGFR3 pulmonary gene expression in the late stages of fetal lung development may disrupt FGFR-mediated alveologenesis resulting in PH in the CDH model.
Title: Upregulation of fibroblast growth factor receptor 2 and 3 in the late stages of fetal lung development in the nitrofen rat model.
These results highlight the importance of the two-way communication back and forth between stroma and epithelium that is mediated by signaling within the FGFR2/3 family during progression to malignancy.
Title: FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression.
FGF7-activated FGFR2IIIb shares a limited subset of phosphotyrosine targets generally associated with FGFR1 and other growth promoting kinases, but also exhibit novel FGFR2IIIb-specific targets associated with growth limitation in the same context.
Title: Novel phosphotyrosine targets of FGFR2IIIb signaling.
demonstrates that FGFR2 in oligodendrocyte (OL) and myelin possess unique characteristics that are specific both to receptor type and to OLs
Title: Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes.
a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling.
Title: Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.
In conclusion, our findings suggest that 5-HT induces GDNF mRNA expression via 5-HT(2)R-mediated FGFR2 transactivation in C6 cells.
Title: Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC20217P1 (e-PCR)
- UniSTS:271885

RH140672 (e-PCR)
- UniSTS:222740

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:507933

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464672

RH143520 (e-PCR)
- UniSTS:232766

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:547904

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464710

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464711

RH11106 (e-PCR)
- UniSTS:7252

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:463447

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:463448

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:508551

BM383187 (e-PCR)
- UniSTS:260750

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464789

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464790

D1Smu5 (e-PCR)
- UniSTS:517816

GDB:554771 (e-PCR)
- UniSTS:157658

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:547827

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:547828

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:143101

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	TAS Traceable Author Statement more info	PubMed
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branch elongation involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bud elongation involved in lung branching	ISO Inferred from Sequence Orthology more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coronal suture morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic pattern specification	ISO Inferred from Sequence Orthology more info
involved_in endochondral bone growth	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within endodermal digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway involved in hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lacrimal gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral sprouting from an epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens fiber cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung lobe morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membranous septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal cell differentiation involved in lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development	ISO Inferred from Sequence Orthology more info
involved_in mesodermal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in orbitofrontal cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otic vesicle formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of urothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate epithelial cord elongation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in pyramidal neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reproductive structure development	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info
acts_upstream_of urothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular zone neuroblast division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor receptor 2

NP_001103362.1

EC 2.7.10.1

NP_001103363.1

EC 2.7.10.1

NP_001103364.1

EC 2.7.10.1

NP_001103365.1

EC 2.7.10.1

NP_001103366.1

EC 2.7.10.1

NP_036844.1

EC 2.7.10.1

XP_006230451.1

EC 2.7.10.1

XP_006230452.1

EC 2.7.10.1

XP_006230455.1

EC 2.7.10.1

XP_063137142.1

EC 2.7.10.1

XP_063137143.1

EC 2.7.10.1

XP_063137147.1

EC 2.7.10.1

XP_063137148.1

EC 2.7.10.1

XP_063137149.1

EC 2.7.10.1

XP_063137153.1

EC 2.7.10.1

XP_063137154.1

EC 2.7.10.1

XP_063137155.1

EC 2.7.10.1

XP_063137158.1

EC 2.7.10.1

XP_063137162.1

EC 2.7.10.1

XP_063137164.1

EC 2.7.10.1

XP_063137168.1

EC 2.7.10.1

XP_063137169.1

EC 2.7.10.1

XP_063137170.1

EC 2.7.10.1

XP_063137171.1

EC 2.7.10.1

XP_063137182.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109892.1 → NP_001103362.1 fibroblast growth factor receptor 2 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (b) lacks an alternate internal exon and contains an alternate internal exon compared to variant a. The resulting isoform (b) has the same N- and C-termini but differs in an internal segment compared to isoform a.

Source sequence(s)

AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19105, L19110

UniProtKB/TrEMBL

F1LNW0

Related

ENSRNOP00000022253.4, ENSRNOT00000022253.8

Conserved Domains (6) summary

cd05857
Location:183 → 267

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:290 → 379

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00410
Location:282 → 378

IG_like; Immunoglobulin like

cd05101
Location:475 → 787

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:500 → 776

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:66 → 143

Ig; Immunoglobulin domain
NM_001109893.1 → NP_001103363.1 fibroblast growth factor receptor 2 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (c) lacks an alternate in-frame exon compared to variant a. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19107, L19110

UniProtKB/TrEMBL

F1LRU8

Related

ENSRNOP00000061479.1, ENSRNOT00000065448.5

Conserved Domains (5) summary

cd04974
Location:201 → 288

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:94 → 178

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:193 → 287

IG_like; Immunoglobulin like

cd05101
Location:387 → 699

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:412 → 688

Pkinase_Tyr; Protein tyrosine kinase
NM_001109894.1 → NP_001103364.1 fibroblast growth factor receptor 2 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (d) lacks an alternate in-frame exon, lacks an alternate internal exon, and contains an alternate internal exon compared to variant a. The resulting isoform (d) has the same N- and C-termini but lacks an internal segment and differs in an internal segment compared to isoform a.

Source sequence(s)

AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19110, L19112

UniProtKB/TrEMBL

Q63236, Q63240, Q63242

Conserved Domains (5) summary

cd05857
Location:94 → 178

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:201 → 290

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00410
Location:193 → 289

IG_like; Immunoglobulin like

cd05101
Location:386 → 698

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:411 → 687

Pkinase_Tyr; Protein tyrosine kinase
NM_001109895.1 → NP_001103365.1 fibroblast growth factor receptor 2 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (e) lacks two alternate in-frame exons compared to variant a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19108, L19110

UniProtKB/TrEMBL

F1LN06

Related

ENSRNOP00000022331.5, ENSRNOT00000022331.8

Conserved Domains (5) summary

cd04974
Location:175 → 262

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:68 → 152

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:167 → 261

IG_like; Immunoglobulin like

cd05101
Location:361 → 673

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:386 → 662

Pkinase_Tyr; Protein tyrosine kinase
NM_001109896.1 → NP_001103366.1 fibroblast growth factor receptor 2 isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (f) lacks two alternate in-frame exons, lacks an alternate internal exon, and contains an alternate internal exon compared to variant a. The resulting isoform (f) has the same N- and C-termini but lacks an internal segment and differs in an internal segment compared to isoform a.

Source sequence(s)

AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19110, L19111, L19112

UniProtKB/TrEMBL

Q63236, Q63240, Q63241, Q63242

Conserved Domains (5) summary

cd05857
Location:68 → 152

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:175 → 264

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00410
Location:167 → 263

IG_like; Immunoglobulin like

cd05101
Location:360 → 672

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:385 → 661

Pkinase_Tyr; Protein tyrosine kinase
NM_012712.1 → NP_036844.1 fibroblast growth factor receptor 2 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19110

UniProtKB/TrEMBL

F1LSG7

Related

ENSRNOP00000059005.1, ENSRNOT00000068183.4

Conserved Domains (5) summary

cd05101
Location:476 → 788

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam18123
Location:391 → 421

FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

cd00096
Location:275 → 278

Ig; Ig strand A [structural motif]

cd05857
Location:173 → 267

IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains

cl11960
Location:275 → 377

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

194175703..194280914 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230393.5 → XP_006230455.1 fibroblast growth factor receptor 2 isoform X13

Conserved Domains (5) summary

cd05857
Location:68 → 152

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:175 → 264

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00410
Location:167 → 263

IG_like; Immunoglobulin like

cd05101
Location:358 → 670

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:383 → 659

Pkinase_Tyr; Protein tyrosine kinase
XM_063281101.1 → XP_063137171.1 fibroblast growth factor receptor 2 isoform X12
XM_063281100.1 → XP_063137170.1 fibroblast growth factor receptor 2 isoform X11

UniProtKB/TrEMBL

F1LN06
XM_063281099.1 → XP_063137169.1 fibroblast growth factor receptor 2 isoform X10
XM_063281098.1 → XP_063137168.1 fibroblast growth factor receptor 2 isoform X9
XM_063281092.1 → XP_063137162.1 fibroblast growth factor receptor 2 isoform X8

UniProtKB/TrEMBL

F1LRU8
XM_006230390.5 → XP_006230452.1 fibroblast growth factor receptor 2 isoform X4

Conserved Domains (6) summary

cd05857
Location:183 → 267

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:290 → 379

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00410
Location:282 → 378

IG_like; Immunoglobulin like

cd05101
Location:473 → 785

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:498 → 774

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:66 → 143

Ig; Immunoglobulin domain
XM_063281085.1 → XP_063137155.1 fibroblast growth factor receptor 2 isoform X6
XM_063281079.1 → XP_063137149.1 fibroblast growth factor receptor 2 isoform X2

UniProtKB/TrEMBL

F1LNW0
XM_006230389.5 → XP_006230451.1 fibroblast growth factor receptor 2 isoform X3

Conserved Domains (6) summary

cd04974
Location:290 → 377

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:183 → 267

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:282 → 376

IG_like; Immunoglobulin like

cd05101
Location:474 → 786

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:499 → 775

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:66 → 143

Ig; Immunoglobulin domain
XM_063281072.1 → XP_063137142.1 fibroblast growth factor receptor 2 isoform X1

UniProtKB/TrEMBL

F1LSG7
XM_063281084.1 → XP_063137154.1 fibroblast growth factor receptor 2 isoform X5
XM_063281078.1 → XP_063137148.1 fibroblast growth factor receptor 2 isoform X1

UniProtKB/TrEMBL

F1LSG7
XM_063281077.1 → XP_063137147.1 fibroblast growth factor receptor 2 isoform X1

UniProtKB/TrEMBL

F1LSG7
XM_063281112.1 → XP_063137182.1 fibroblast growth factor receptor 2 isoform X14
XM_063281094.1 → XP_063137164.1 fibroblast growth factor receptor 2 isoform X8

UniProtKB/TrEMBL

F1LRU8
XM_063281083.1 → XP_063137153.1 fibroblast growth factor receptor 2 isoform X4
XM_063281073.1 → XP_063137143.1 fibroblast growth factor receptor 2 isoform X1

UniProtKB/TrEMBL

F1LSG7
XM_063281088.1 → XP_063137158.1 fibroblast growth factor receptor 2 isoform X7