Pgam2 phosphoglycerate mutase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pgam2provided by RGD
Official Full Name: phosphoglycerate mutase 2provided by RGD
Primary source: RGD:3313
See related: EnsemblRapid:ENSRNOG00000013532 AllianceGenome:RGD:3313
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pgmut; PGAM-M; D14Mgh1
Summary: Enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity. Involved in gluconeogenesis; response to mercury ion; and spermatogenesis. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 21121.2) and Heart (RPKM 4038.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (84895763..84897874, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (80681796..80683907, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (86045005..86047116, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW527377 (e-PCR)
- UniSTS:246030

D14Rat19 (e-PCR)
- UniSTS:118359

D14Mgh1 (e-PCR)
- UniSTS:119442

Pgam2 (e-PCR), detects polymorphism
- UniSTS:507135

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables bisphosphoglycerate mutase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphoglycerate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in response to mercury ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in striated muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphoglycerate mutase 2

Names: BPG-dependent PGAM 2; muscle-specific phosphoglycerate mutase; phosphoglycerate mutase 2 (muscle); phosphoglycerate mutase isozyme M

NP_059024.1

EC 5.4.2.11

EC 5.4.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.