Dmd dystrophin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dmdprovided by RGD
Official Full Name: dystrophinprovided by RGD
Primary source: RGD:2507
See related: EnsemblRapid:ENSRNOG00000046366 AllianceGenome:RGD:2507
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DNADMD1
Summary: Enables several functions, including PDZ domain binding activity; integrin binding activity; and lamin binding activity. Involved in several processes, including nervous system development; regulation of neuron differentiation; and response to denervation involved in regulation of muscle adaptation. Located in several cellular components, including mitochondrial membrane; neurofilament; and secretory vesicle. Part of dystrophin-associated glycoprotein complex. Used to study Duchenne muscular dystrophy; brain edema; and dilated cardiomyopathy. Biomarker of muscular atrophy; retinal degeneration; and status epilepticus. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to human DMD (dystrophin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 256.1), Muscle (RPKM 255.7) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: Xq21

Exon count:: 84

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (51070098..53437845)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (47272324..49504219)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (51149358..53519271)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and characterization of dystrophin-locus-derived testis-specific protein: A testis-specific gene within the intronic region of the rat dystrophin gene.
Title: Identification and characterization of dystrophin-locus-derived testis-specific protein: A testis-specific gene within the intronic region of the rat dystrophin gene.
Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene-mutated rats.
Title: Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene-mutated rats.
Nuclear transport and subcellular localization of the dystrophin Dp71 and Dp40 isoforms in the PC12 cell line.
Title: Nuclear transport and subcellular localization of the dystrophin Dp71 and Dp40 isoforms in the PC12 cell line.
Overexpression of the dystrophins Dp40 and Dp40L170P modifies neurite outgrowth and the protein expression profile of PC12 cells.
Title: Overexpression of the dystrophins Dp40 and Dp40(L170P) modifies neurite outgrowth and the protein expression profile of PC12 cells.
Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy.
Title: Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy.
Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy.
Title: Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy.
the effect of Dp71eDelta71 overexpression on neuronal differentiation of PC12 Tet-On cells
Title: The dystrophin isoform Dp71e(Δ71) is involved in neurite outgrowth and neuronal differentiation of PC12 cells.
Dystrophin is expressed in smooth muscle cells and afferent nerve fibers in the urinary bladder. Dp71 was expressed two- to threefold higher compared with Dp140, independently of age.
Title: Dystrophin is expressed in smooth muscle and afferent nerve fibers in the rat urinary bladder.
The results indicated that the expression levels of Dp71 are posttranslationally regulated by the phosphorylation-ubiquitin-proteasomal pathway, which may indicate the presence of regulatory mechanisms underlying the proteostasis of both Dp and its molecular complex, which may lead to better therapeutic approaches for the treatment of Dp-related diseases.
Title: Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.
that decreased expression of dystrophin and increased expression of calpains are coincident and could work as possible therapeutic targets to prevent heart failure as a consequence of cardiac hypertrophy
Title: Early dystrophin loss is coincident with the transition of compensated cardiac hypertrophy to heart failure.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

DMD (e-PCR)
- UniSTS:99128

DXMit8.3 (e-PCR), detects polymorphism
- UniSTS:132187

DMD (e-PCR)
- UniSTS:99474

DXWox19 (e-PCR)
- UniSTS:517795

BE121015 (e-PCR)
- UniSTS:247998

DXWox18 (e-PCR)
- UniSTS:517853

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables lamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within connective tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of blood-nerve barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of glial blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in muscle cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-cysteine S-nitrosylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleus localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within olfactory nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in peptide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in response to denervation involved in regulation of muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to muscle stretch	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within walking behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-substrate junction	ISO Inferred from Sequence Orthology more info
located_in costamere	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dystrophin-associated glycoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in matrix side of mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in neurofilament	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: dystrophin

Names: apodystrophin-3; apodystrophin-I; dystrophin, muscular dystrophy; dystrophin-related

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005244.2 → NP_001005244.1 dystrophin isoform Dp71ab

See identical proteins and their annotated locations for NP_001005244.1

Status: VALIDATED

Description

Transcript Variant: This variant (Dp71ab) lacks an exon in the 3' coding region, resulting in a frameshift, as compared to variant Dp71a. The encoded isoform Dp71ab has a longer and distinct C-terminus, as compared to isoform Dp71a.

Source sequence(s)

AY326948

UniProtKB/TrEMBL

A0A0G2K2Z6, F1LN35, Q7TPH3

Conserved Domains (4) summary

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:21 → 139

EF-hand_2; EF hand

pfam09069
Location:143 → 234

EF-hand_3; EF-hand

pfam16769
Location:407 → 600

MCM3AP_GANP; MCM3AP domain of GANP
NM_001005246.1 → NP_001005246.1 dystrophin isoform Dp71c

See identical proteins and their annotated locations for NP_001005246.1

Status: VALIDATED

Description

Transcript Variant: This variant (Dp71c) lacks an in-frame segment including three exons in the coding region, as compared to variant Dp71a. The encoded isoform 71c lacks an internal segment, as compared to isoform Dp71a.

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0F7CRZ7, Q7TPH2

Conserved Domains (3) summary

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam16769
Location:358 → 493

MCM3AP_GANP; MCM3AP domain of GANP

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin
NM_001370876.1 → NP_001357805.1 dystrophin isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

F1M705, P11530

Related

ENSRNOP00000029969.6, ENSRNOT00000035692.8

Conserved Domains (7) summary

COG5069
Location:12 → 232

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3051 → 3080

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3303 → 3351

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1127 → 2060

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3117 → 3278

EFh_DMD; EF-hand-like motif found in dystrophin

cl02488
Location:561 → 781

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_012698.3 → NP_036830.2 dystrophin isoform Dp71a

See identical proteins and their annotated locations for NP_036830.2

Status: VALIDATED

Description

Transcript Variant: This variant (Dp71a) consists of 17 exons and encodes isoform Dp71a.

Source sequence(s)

AY326947

UniProtKB/TrEMBL

F5CC78, Q7TPH4

Conserved Domains (3) summary

COG1196
Location:354 → 524

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

51070098..53437845

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279795.1 → XP_063135865.1 dystrophin isoform X2

Related

ENSRNOP00000111691.1, ENSRNOT00000125414.1
XM_063279798.1 → XP_063135868.1 dystrophin isoform X7
XM_063279800.1 → XP_063135870.1 dystrophin isoform X9
XM_063279801.1 → XP_063135871.1 dystrophin isoform X10

Related

ENSRNOP00000074105.2, ENSRNOT00000091467.3
XM_063279797.1 → XP_063135867.1 dystrophin isoform X6
XM_017601909.3 → XP_017457398.1 dystrophin isoform X3
XM_063279794.1 → XP_063135864.1 dystrophin isoform X1
XM_063279799.1 → XP_063135869.1 dystrophin isoform X8
XM_063279796.1 → XP_063135866.1 dystrophin isoform X4

UniProtKB/TrEMBL

A0A8I6GKZ8

Related

ENSRNOP00000095060.1, ENSRNOT00000094721.2
XM_039099484.2 → XP_038955412.1 dystrophin isoform X5

Conserved Domains (9) summary

cd00176
Location:309 → 523

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3015 → 3044

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3267 → 3315

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1091 → 2024

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3081 → 3242

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2890 → 2996

Spectrin; Spectrin repeat

cd21233
Location:100 → 210

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl00030
Location:17 → 85

CH_SF; calponin homology (CH) domain superfamily

cl02488
Location:525 → 745

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063279802.1 → XP_063135872.1 dystrophin isoform X11
XM_063279803.1 → XP_063135873.1 dystrophin isoform X12
XM_063279804.1 → XP_063135874.1 dystrophin isoform X13
XM_063279805.1 → XP_063135875.1 dystrophin isoform X14
XM_008773252.4 → XP_008771474.1 dystrophin isoform X15

UniProtKB/TrEMBL

A0A0G2K2Z6, A0A8J8Y3R2

Related

ENSRNOP00000032859.5, ENSRNOT00000034372.8

Conserved Domains (4) summary

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:21 → 139

EF-hand_2; EF hand

pfam09069
Location:143 → 234

EF-hand_3; EF-hand

pfam16769
Location:420 → 613

MCM3AP_GANP; MCM3AP domain of GANP
XM_008773253.4 → XP_008771475.1 dystrophin isoform X16

See identical proteins and their annotated locations for XP_008771475.1

UniProtKB/TrEMBL

F5CC78

Conserved Domains (3) summary

COG1196
Location:367 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin