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Esr1 estrogen receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24890, updated on 14-Nov-2024

Summary

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Official Symbol: Esr1provided by RGD
Official Full Name: estrogen receptor 1provided by RGD
Primary source: RGD:2581
See related: EnsemblRapid:ENSRNOG00000019358 AllianceGenome:RGD:2581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Esr; ER-alpha; RNESTROR
Summary: Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of signal transduction; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Esr1 in Genome Data Viewer

Location:: 1q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (43511685..43904454)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (41106335..41499104)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (41192029..41594799)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.
Title: The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.
Effect of estrogen receptor alpha on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model.
Title: Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model.
Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERalpha/PI3K/Akt signaling pathway.
Title: Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERα/PI3K/Akt signaling pathway.
ERalpha Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core.
Title: ERα Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core.
Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Title: Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Decrease in ERa within the BNST of sexually naive male rats following an encounter with a novel female.
Title: Decrease in ERɑ within the BNST of sexually naïve male rats following an encounter with a novel female.
The role of estrogen receptor manipulation during traumatic stress on changes in emotional memory induced by traumatic stress.
Title: The role of estrogen receptor manipulation during traumatic stress on changes in emotional memory induced by traumatic stress.
Activation of the NLRP3/IL-1beta/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERalpha and Sirt1 in oophorectomized rats.
Title: Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats.
Estrogen receptor alpha activation modulates the gut microbiome and type 2 diabetes risk factors.
Title: Estrogen receptor α activation modulates the gut microbiome and type 2 diabetes risk factors.
Sex-specific effects of 17beta-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERalpha and ERbeta and require palmitoylation to translocate the receptors to the plasma membrane.
Title: Sex-specific effects of 17β-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERα and ERβ and require palmitoylation to translocate the receptors to the plasma membrane.

Submit: New GeneRIF Correction See all GeneRIFs (306)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU047540 (e-PCR)
- UniSTS:110408

Esr1 (e-PCR), detects polymorphism
- UniSTS:256888

RH94746 (e-PCR)
- UniSTS:119993

Esr1 (e-PCR), detects polymorphism
- UniSTS:257222

Esr1 (e-PCR), detects polymorphism
- UniSTS:257223

Esr1 (e-PCR), detects polymorphism
- UniSTS:275685

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables G protein-coupled estrogen receptor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables TFIIB-class transcription factor binding	IEA Inferred from Electronic Annotation more info
enables TFIIB-class transcription factor binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables estrogen response element binding	IEA Inferred from Electronic Annotation more info
enables estrogen response element binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables type 1 metabotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in Sertoli cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in Sertoli cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in androgen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in antral ovarian follicle growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antral ovarian follicle growth	ISO Inferred from Sequence Orthology more info
involved_in baculum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estrogen stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to wortmannin	IEP Inferred from Expression Pattern more info	PubMed
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in mammary gland duct elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation	ISO Inferred from Sequence Orthology more info
involved_in estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland branching involved in pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland branching involved in pregnancy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast development	IEP Inferred from Expression Pattern more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in prostate epithelial cord elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate epithelial cord elongation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of branching involved in prostate gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in uterus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info
involved_in vagina development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vagina development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estrogen receptor

Names: C-terminally-truncated estrogen receptor alpha product-1; Er alpha; estradiol receptor; estrogen receptor 1 (alpha); estrogen receptor alpha i45aL; estrogen receptor alpha i45aS; estrogen receptor alpha i45c; estrogen receptor alpha i56a; estrogen receptor alpha i56b; estrogen receptor alpha i56c; estrogen receptor alpha i56dL; estrogen receptor alpha i56dS; estrogen receptor alpha i56e; estrogen receptor alpha variant delta 4; estrogen receptor protein; nuclear receptor subfamily 3 group A member 1; trunctaed estrogen receptor product-1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433730.1 → NP_001420659.1 estrogen receptor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001433731.1 → NP_001420660.1 estrogen receptor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_012689.2 → NP_036821.2 estrogen receptor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000071400.1, ENSRNOT00000078494.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

43511685..43904454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101049.2 → XP_038956977.1 estrogen receptor isoform X3

UniProtKB/TrEMBL

A0A1W7GYV1

Conserved Domains (3) summary

cd07171
Location:218 → 299

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:75 → 219

Oest_recep; Oestrogen receptor

cl11397
Location:348 → 454

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_017588797.3 → XP_017444286.2 estrogen receptor isoform X6

UniProtKB/TrEMBL

A0A0G2K0D4

Conserved Domains (4) summary

cd06949
Location:348 → 617

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:218 → 299

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:75 → 219

Oest_recep; Oestrogen receptor

pfam12743
Location:626 → 665

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_039101051.2 → XP_038956979.1 estrogen receptor isoform X4

UniProtKB/TrEMBL

A0A8I6AKJ6

Conserved Domains (3) summary

cd07171
Location:218 → 299

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:75 → 219

Oest_recep; Oestrogen receptor

cl11397
Location:348 → 450

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_039101033.2 → XP_038956961.1 estrogen receptor isoform X1

UniProtKB/TrEMBL

A6KIM0

Conserved Domains (4) summary

cd06949
Location:348 → 585

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:218 → 299

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:75 → 219

Oest_recep; Oestrogen receptor

pfam12743
Location:594 → 633

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_039101029.2 → XP_038956957.1 estrogen receptor isoform X1

UniProtKB/TrEMBL

A6KIM0

Conserved Domains (4) summary

cd06949
Location:348 → 585

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:218 → 299

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:75 → 219

Oest_recep; Oestrogen receptor

pfam12743
Location:594 → 633

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_017588795.3 → XP_017444284.1 estrogen receptor isoform X2

UniProtKB/TrEMBL

A0A0G2JZG2, A0A9K3Y766, D0FYH4, F1M839

Conserved Domains (4) summary

cd06949
Location:315 → 552

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:185 → 266

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 186

Oest_recep; Oestrogen receptor

pfam12743
Location:561 → 600

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_006227832.5 → XP_006227894.1 estrogen receptor isoform X2

See identical proteins and their annotated locations for XP_006227894.1

UniProtKB/TrEMBL

A0A0G2JZG2, A0A9K3Y766, D0FYH4, F1M839

Conserved Domains (4) summary

cd06949
Location:315 → 552

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:185 → 266

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 186

Oest_recep; Oestrogen receptor

pfam12743
Location:561 → 600

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_008758704.4 → XP_008756926.1 estrogen receptor isoform X2

See identical proteins and their annotated locations for XP_008756926.1

UniProtKB/TrEMBL

A0A0G2JZG2, A0A9K3Y766, D0FYH4, F1M839

Conserved Domains (4) summary

cd06949
Location:315 → 552

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:185 → 266

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 186

Oest_recep; Oestrogen receptor

pfam12743
Location:561 → 600

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_063281065.1 → XP_063137135.1 estrogen receptor isoform X2

UniProtKB/TrEMBL

A0A9K3Y766, D0FYH4, F1M839
XM_017588796.3 → XP_017444285.1 estrogen receptor isoform X5