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    Amdhd2 amidohydrolase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 245847, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Amdhd2provided by MGI
    Official Full Name
    amidohydrolase domain containing 2provided by MGI
    Primary source
    MGI:MGI:2443978
    See related
    Ensembl:ENSMUSG00000036820 AllianceGenome:MGI:2443978
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730457F11Rik
    Summary
    Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process. Is expressed in axial skeleton and nucleus pulposus. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 72.5), testis adult (RPKM 49.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Amdhd2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.28 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24374807..24382752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24155833..24163733, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E8657 Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42072 Neighboring gene STARR-seq mESC enhancer starr_42074 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24274163-24274452 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409 Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene netrin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Kroef V, et al. Elife, 2022 Mar 1. PMID 35229715, Free PMC Article
    2. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
    3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylgalactosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylglucosamine-6-phosphate deacetylase
    Names
    amidohydrolase domain-containing protein 2
    glcNAc 6-P deacetylase
    putative N-acetylglucosamine-6-phosphate deacetylase
    NP_766523.2
    XP_036016505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172935.4 → NP_766523.2  N-acetylglucosamine-6-phosphate deacetylase

      See identical proteins and their annotated locations for NP_766523.2

      Status: PROVISIONAL

      Source sequence(s)
      CT010502
      Consensus CDS
      CCDS28475.1
      UniProtKB/Swiss-Prot
      Q8BK10, Q8JZV7
      UniProtKB/TrEMBL
      F7CUP3
      Related
      ENSMUSP00000036141.6, ENSMUST00000040735.12
      Conserved Domains (2) summary
      COG1228
      Location:31 → 401
      HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
      cd00854
      Location:13 → 398
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24374807..24382752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160612.1 → XP_036016505.1  N-acetylglucosamine-6-phosphate deacetylase isoform X1

      UniProtKB/TrEMBL
      F6UP77, F7CUP3
      Related
      ENSMUSP00000120520.3, ENSMUST00000129523.3
      Conserved Domains (1) summary
      cd00854
      Location:13 → 442
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZV7.1 GenPept UniProtKB/Swiss-Prot:Q8JZV7

    Gene LinkOut

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