Muc2 mucin 2, oligomeric mucus/gel-forming [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Muc2provided by RGD
Full Name: mucin 2, oligomeric mucus/gel-formingprovided by RGD
Primary source: RGD:3123
See related: EnsemblRapid:ENSRNOG00000046602 AllianceGenome:RGD:3123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MLP; HH-Muc; AABR07006030.1
Summary: Enables identical protein binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to lipopolysaccharide; and response to vitamin A. Located in cytoplasm; mucus layer; and nucleus. Used to study colitis; intestinal disease; and pneumonia. Biomarker of several diseases, including colitis (multiple); colon cancer; liver cirrhosis; mucositis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2.4), Adrenal (RPKM 1.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (206225775..206261280)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196799494..196831740)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214663929..214693197)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Colonic mucin-2 attenuates acute necrotizing pancreatitis in rats by modulating intestinal homeostasis.
Title: Colonic mucin-2 attenuates acute necrotizing pancreatitis in rats by modulating intestinal homeostasis.
Intestinal microbiota profiles in a genetic model of colon tumorigenesis correlates with colon cancer biomarkers.
Title: Intestinal microbiota profiles in a genetic model of colon tumorigenesis correlates with colon cancer biomarkers.
Bacterial overgrowth associated with bacterial translocation is linked to intestinal over-expression of IFN-gamma, IL-4, IL-17 and mucin-2 in cholestasis.
Title: Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats.
In obstructive jaundice condition, goblet cells and MUC2 were reduced which were involved in the damage of intestinal mucosa barrier; biliary drainage increased goblet cells and MUC2, repaired mucosa layer and restored the intestinal mucosa barrier function.
Title: Internal biliary drainage superior to external biliary drainage in improving gut mucosa barrier because of goblet cells and mucin-2 up-regulation.
The data obtained may indicate involvement of genes Tlr2, Muc2, Defa in development of inflammation in the duodenum due to dysbiotic changes under conditions of prolonged hypochlorhydria.
Title: Expression of Tlr2, Defa, Muc2 genes in rat duodenal upon long-term gastric hypacidity and with multiprobiotic correction.
Rat Muc2 was expressed in fetal intestinal goblet cells of surface epithelium of villi and developing Lieberkuhn crypts. In neonates and adults, Muc2 was expressed at luminal goblet cells of small and large intestine and at gastric mucous and glandular cells. Muc5ac protein was observed in embryonic gastric and lung samples; expression increased during development and postnatal and adult life.
Title: Temporal and spatial expression of Muc2 and Muc5ac mucins during rat respiratory and digestive tracts development.
Data suggest that expression of Muc2 in mucosa of jejunum can be upregulated by dietary factors (here, apple pectins as dietary supplements).
Title: Low-methoxyl pectin stimulates small intestinal mucin secretion irrespective of goblet cell proliferation and is characterized by jejunum Muc2 upregulation in rats.
the repeated exposure to water immersion stress decreases Muc2 synthesis in the goblet cells via decreased Cdx2 expression
Title: Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms.
These results indicate that mucin plays an important role in the preservation of the mucosal barrier and that ischemia but not digestive enzymes disturbs mucin integrity, while digestive enzymes actively mediate epithelial cell disruption.
Title: Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine.
Active transport of bile acids decreases mucin 2 in neonatal ileum, which has implications for development of necrotizing enterocolitis
Title: Active transport of bile acids decreases mucin 2 in neonatal ileum: implications for development of necrotizing enterocolitis.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

Muc2 (e-PCR), detects polymorphism
- UniSTS:530706

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cupric ion binding	ISO Inferred from Sequence Orthology more info
enables cupric ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in detoxification of copper ion	ISO Inferred from Sequence Orthology more info
involved_in detoxification of copper ion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glandular epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in host-mediated regulation of intestinal microbiota composition	ISO Inferred from Sequence Orthology more info
involved_in host-mediated regulation of intestinal microbiota composition	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
involved_in maintenance of gastrointestinal epithelium	ISS Inferred from Sequence or Structural Similarity more info
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to transforming growth factor beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in inner mucus layer	ISO Inferred from Sequence Orthology more info
located_in inner mucus layer	ISS Inferred from Sequence or Structural Similarity more info
located_in mucus layer	IDA Inferred from Direct Assay more info	PubMed
is_active_in mucus layer	ISO Inferred from Sequence Orthology more info
located_in outer mucus layer	ISO Inferred from Sequence Orthology more info
located_in outer mucus layer	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mucin-2

Names: MUC-2; intestinal mucin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.