Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmc4provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4provided by MGI
Primary source: MGI:MGI:1346093
See related: Ensembl:ENSMUSG00000030603 AllianceGenome:MGI:1346093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CIP21; MIP224
Summary: Predicted to enable proteasome-activating activity. Acts upstream of or within blastocyst development. Part of proteasome accessory complex. Is expressed in several structures, including cranial ganglion; early conceptus; gonad; liver lobe; and submandibular gland primordium. Used to study amyotrophic lateral sclerosis. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 88.1), CNS E14 (RPKM 71.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 16.11 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27741127..27749517, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28041702..28050092, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Psmc4 (e-PCR), detects polymorphism
- UniSTS:498274

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of cytosolic proteasome complex	IEA Inferred from Electronic Annotation more info
part_of cytosolic proteasome complex	ISO Inferred from Sequence Orthology more info
located_in inclusion body	IEA Inferred from Electronic Annotation more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 6B

Names: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; CAR interacing protein 21; CAR interacting protein 21; MB67-interacting protein; TAT-binding protein 7; TBP-7; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.