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    Dip2b disco interacting protein 2 homolog B [ Mus musculus (house mouse) ]

    Gene ID: 239667, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dip2bprovided by MGI
    Official Full Name
    disco interacting protein 2 homolog Bprovided by MGI
    Primary source
    MGI:MGI:2145977
    See related
    Ensembl:ENSMUSG00000023026 AllianceGenome:MGI:2145977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1463; 4932422C22
    Summary
    Enables alpha-tubulin binding activity. Involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Located in axon; dendrite; and perikaryon. Is expressed in several structures, including central nervous system; gut; liver; retina; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.4), whole brain E14.5 (RPKM 8.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dip2b in Genome Data Viewer
    Location:
    15 F1; 15 56.14 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99935119..100117355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100037626..100219474)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member A Neighboring gene predicted gene, 21917 Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3157 Neighboring gene La ribonucleoprotein 4 Neighboring gene STARR-seq mESC enhancer starr_39735 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99890852-99891153 Neighboring gene STARR-seq mESC enhancer starr_39737 Neighboring gene STARR-seq mESC enhancer starr_39738 Neighboring gene STARR-seq mESC enhancer starr_39739 Neighboring gene STARR-seq mESC enhancer starr_39742 Neighboring gene STARR-seq mESC enhancer starr_39744 Neighboring gene STARR-seq mESC enhancer starr_39745 Neighboring gene activating transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_39746 Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene transmembrane (C-terminal) protease, serine 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Dip2b leads to abnormal neural differentiation from mESCs. Yao M, et al. Stem Cell Res Ther, 2023 Sep 13. PMID 37705068, Free PMC Article
    2. Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment. Adlat S, et al. Int Immunopharmacol, 2022 Apr. PMID 35091337
    3. Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene. Sah RK, et al. Curr Issues Mol Biol, 2021 Jun 30. PMID 34208944, Free PMC Article
    4. DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth. Xing ZK, et al. Front Cell Neurosci, 2020. PMID 32153366, Free PMC Article
    5. CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. Winnepenninckx B, et al. Am J Hum Genet, 2007 Feb. PMID 17236128, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Dip2b leads to abnormal neural differentiation from mESCs.
      Title: Loss of Dip2b leads to abnormal neural differentiation from mESCs.
    2. Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment.
      Title: Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment.
    3. Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene.
      Title: Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene.
    4. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.
      Title: Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1463

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disco-interacting protein 2 homolog B
    Names
    DIP2 disco-interacting protein 2 homolog B
    DIP2 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159361.3 → NP_001152833.1  disco-interacting protein 2 homolog B isoform 1

      See identical proteins and their annotated locations for NP_001152833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC124479, AC125526, AC133868
      Consensus CDS
      CCDS49731.1
      UniProtKB/Swiss-Prot
      Q3UH60, Q8C1W5, Q8CDG9, Q8CHA2
      Related
      ENSMUSP00000097777.4, ENSMUST00000100203.10
      Conserved Domains (4) summary
      COG0318
      Location:334 → 910
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:993 → 1468
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:358 → 922
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_001402901.1 → NP_001389830.1  disco-interacting protein 2 homolog B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124479, AC125526, AC133868

    3. NM_172819.4 → NP_766407.2  disco-interacting protein 2 homolog B isoform 2

      See identical proteins and their annotated locations for NP_766407.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC124479, AC125526
      Consensus CDS
      CCDS27831.1
      UniProtKB/TrEMBL
      B2RQC7, D3Z5G8
      Related
      ENSMUSP00000023768.8, ENSMUST00000023768.14
      Conserved Domains (3) summary
      COG0318
      Location:100 → 676
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:759 → 1234
      AMP-binding; AMP-binding enzyme
      cl17068
      Location:124 → 688
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99935119..100117355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245629.4 → XP_011243931.1  disco-interacting protein 2 homolog B isoform X1

      Conserved Domains (2) summary
      cd05905
      Location:1050 → 1615
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    2. XM_011245630.4 → XP_011243932.1  disco-interacting protein 2 homolog B isoform X2

      Conserved Domains (2) summary
      cd05905
      Location:1049 → 1614
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    3. XM_011245631.4 → XP_011243933.1  disco-interacting protein 2 homolog B isoform X4

      Conserved Domains (2) summary
      cd05905
      Location:979 → 1544
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    4. XM_011245632.4 → XP_011243934.1  disco-interacting protein 2 homolog B isoform X5

      Conserved Domains (2) summary
      cd05905
      Location:978 → 1543
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UH60.1 GenPept UniProtKB/Swiss-Prot:Q3UH60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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