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    Mapk7 mitogen-activated protein kinase 7 [ Mus musculus (house mouse) ]

    Gene ID: 23939, updated on 14-Nov-2024

    Summary

    Official Symbol
    Mapk7provided by MGI
    Official Full Name
    mitogen-activated protein kinase 7provided by MGI
    Primary source
    MGI:MGI:1346347
    See related
    Ensembl:ENSMUSG00000001034 AllianceGenome:MGI:1346347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BMK1; ERK5; BMK-1; ERK-5; PRKM7; Erk5-T; b2b2346Clo
    Summary
    Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including negative regulation of calcineurin-NFAT signaling cascade; peptidyl-serine phosphorylation; and regulation of angiogenesis. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; gonad; nervous system; and salivary gland. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 31.7), whole brain E14.5 (RPKM 29.9) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mapk7 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61379638..61385101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61488812..61494267, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 112 Neighboring gene STARR-positive B cell enhancer ABC_E6995 Neighboring gene microfibrillar-associated protein 4 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene epsin 2 Neighboring gene STARR-seq mESC enhancer starr_29682

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERK5 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to laminar fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to laminar fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 7
    Names
    MAPK 7
    big MAP kinase 1
    extracellular signal-regulated kinase 5
    NP_001277962.1
    NP_001277963.1
    NP_001277964.1
    NP_001277965.1
    NP_001277966.1
    NP_001348918.1
    NP_035971.1
    XP_006533340.1
    XP_006533343.1
    XP_006533347.1
    XP_006533348.1
    XP_006533349.1
    XP_030101845.1
    XP_030101846.1
    XP_030101847.1
    XP_030101848.1
    XP_030101849.1
    XP_030101850.1
    XP_030101851.1
    XP_030101853.1
    XP_036012575.1
    XP_036012576.1
    XP_036012577.1
    XP_036012578.1
    XP_036012579.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291033.1NP_001277962.1  mitogen-activated protein kinase 7 isoform b

      See identical proteins and their annotated locations for NP_001277962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF126160, AY534740, BY207876
      Consensus CDS
      CCDS70205.1
      UniProtKB/Swiss-Prot
      Q9WVS8
      Related
      ENSMUSP00000104354.2, ENSMUST00000108714.2
      Conserved Domains (1) summary
      cd07855
      Location:6315
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    2. NM_001291034.1NP_001277963.1  mitogen-activated protein kinase 7 isoform a

      See identical proteins and their annotated locations for NP_001277963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AY534740, BC100398, BY207876
      Consensus CDS
      CCDS24814.1
      UniProtKB/Swiss-Prot
      Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8
      Conserved Domains (1) summary
      cd07855
      Location:49384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    3. NM_001291035.1NP_001277964.1  mitogen-activated protein kinase 7 isoform c

      See identical proteins and their annotated locations for NP_001277964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AY534740, BC082315, BY207876
      UniProtKB/Swiss-Prot
      Q9WVS8
      Related
      ENSMUST00000152755.8
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001291036.1NP_001277965.1  mitogen-activated protein kinase 7 isoform c

      See identical proteins and their annotated locations for NP_001277965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AY534740, BY207876, CA320276
      UniProtKB/Swiss-Prot
      Q9WVS8
      Related
      ENSMUST00000125840.8
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001291037.1NP_001277966.1  mitogen-activated protein kinase 7 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF126161, AY534740, BC058096, BY207876
      Consensus CDS
      CCDS78963.1
      UniProtKB/TrEMBL
      Q5NCN8
      Related
      ENSMUSP00000098646.3, ENSMUST00000101085.9
      Conserved Domains (2) summary
      smart00220
      Location:8277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:8314
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    6. NM_001361989.1NP_001348918.1  mitogen-activated protein kinase 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AY534740, BB868535, BC082315, CA315160
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    7. NM_011841.2NP_035971.1  mitogen-activated protein kinase 7 isoform a

      See identical proteins and their annotated locations for NP_035971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AY534740, BY207876
      Consensus CDS
      CCDS24814.1
      UniProtKB/Swiss-Prot
      Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8
      Related
      ENSMUSP00000078087.7, ENSMUST00000079080.13
      Conserved Domains (1) summary
      cd07855
      Location:49384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61379638..61385101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533277.5XP_006533340.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006533340.1

      UniProtKB/Swiss-Prot
      Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8
      Conserved Domains (1) summary
      cd07855
      Location:49384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    2. XM_030245986.2XP_030101846.1  mitogen-activated protein kinase 7 isoform X2

      Conserved Domains (1) summary
      cd07855
      Location:6315
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    3. XM_030245993.2XP_030101853.1  mitogen-activated protein kinase 7 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    4. XM_030245989.2XP_030101849.1  mitogen-activated protein kinase 7 isoform X3

      Conserved Domains (1) summary
      cd07855
      Location:8314
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    5. XM_006533285.5XP_006533348.1  mitogen-activated protein kinase 7 isoform X4

      See identical proteins and their annotated locations for XP_006533348.1

      UniProtKB/Swiss-Prot
      Q9WVS8
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    6. XM_036156683.1XP_036012576.1  mitogen-activated protein kinase 7 isoform X3

      Conserved Domains (1) summary
      cd07855
      Location:8314
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    7. XM_006533284.5XP_006533347.1  mitogen-activated protein kinase 7 isoform X4

      See identical proteins and their annotated locations for XP_006533347.1

      UniProtKB/Swiss-Prot
      Q9WVS8
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    8. XM_030245987.2XP_030101847.1  mitogen-activated protein kinase 7 isoform X3

      Conserved Domains (1) summary
      cd07855
      Location:8314
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    9. XM_036156684.1XP_036012577.1  mitogen-activated protein kinase 7 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    10. XM_030245988.2XP_030101848.1  mitogen-activated protein kinase 7 isoform X3

      Conserved Domains (1) summary
      cd07855
      Location:8314
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    11. XM_006533286.5XP_006533349.1  mitogen-activated protein kinase 7 isoform X4

      See identical proteins and their annotated locations for XP_006533349.1

      UniProtKB/Swiss-Prot
      Q9WVS8
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    12. XM_036156686.1XP_036012579.1  mitogen-activated protein kinase 7 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    13. XM_030245985.2XP_030101845.1  mitogen-activated protein kinase 7 isoform X2

      Conserved Domains (1) summary
      cd07855
      Location:6315
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    14. XM_036156685.1XP_036012578.1  mitogen-activated protein kinase 7 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    15. XM_036156682.1XP_036012575.1  mitogen-activated protein kinase 7 isoform X3

      Conserved Domains (1) summary
      cd07855
      Location:8314
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    16. XM_030245990.2XP_030101850.1  mitogen-activated protein kinase 7 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    17. XM_030245991.2XP_030101851.1  mitogen-activated protein kinase 7 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    18. XM_006533280.5XP_006533343.1  mitogen-activated protein kinase 7 isoform X4

      See identical proteins and their annotated locations for XP_006533343.1

      UniProtKB/Swiss-Prot
      Q9WVS8
      Conserved Domains (1) summary
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain