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    C1qtnf9 C1q and tumor necrosis factor related protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 239126, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C1qtnf9provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 9provided by MGI
    Primary source
    MGI:MGI:3045252
    See related
    Ensembl:ENSMUSG00000071347 AllianceGenome:MGI:3045252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adif1; CTRP9; Ciqtnf9; 9130217G22Rik
    Summary
    Enables hormone activity and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of cell size; positive regulation of cellular response to insulin stimulus; and positive regulation of protein serine/threonine kinase activity. Located in extracellular space. Is expressed in several structures, including adipose tissue; genitourinary system; hemolymphoid system; liver; and musculature. Orthologous to human C1QTNF9 (C1q and TNF related 9) and C1QTNF9B (C1q and TNF related 9B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 18.3), subcutaneous fat pad adult (RPKM 17.1) and 6 other tissues See more
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    Genomic context

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    See C1qtnf9 in Genome Data Viewer
    Location:
    14 D1; 14 31.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61005583..61018318)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60768134..60780869)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61328022-61328292 Neighboring gene predicted gene, 41165 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61351140-61351293 Neighboring gene STARR-seq mESC enhancer starr_36862 Neighboring gene STARR-positive B cell enhancer mm9_chr14:61357423-61357724 Neighboring gene STARR-seq mESC enhancer starr_36864 Neighboring gene STARR-positive B cell enhancer mm9_chr14:61418588-61418889 Neighboring gene predicted gene, 34997 Neighboring gene mitochondrial intermediate peptidase, opposite strand Neighboring gene STARR-seq mESC enhancer starr_36865 Neighboring gene mitochondrial intermediate peptidase Neighboring gene STARR-seq mESC enhancer starr_36867 Neighboring gene STARR-seq mESC enhancer starr_36869 Neighboring gene STARR-seq mESC enhancer starr_36870 Neighboring gene tumor necrosis factor receptor superfamily, member 19 Neighboring gene VISTA enhancer mm7 Neighboring gene STARR-seq mESC enhancer starr_36873 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61665054-61665237 Neighboring gene predicted gene, 41167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation. Sun Y, et al. Circulation, 2013 Sep 10. PMID 24030394, Free PMC Article
    2. Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals. Wang W, et al. Cardiovasc Diabetol, 2016 Jan 11. PMID 26754066, Free PMC Article
    3. Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation. Zhang P, et al. Mol Cell Biochem, 2016 Jun. PMID 27188183
    4. CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet. Guan H, et al. Front Biosci (Landmark Ed), 2024 Jun 25. PMID 38940054
    5. C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Yan W, et al. Circulation, 2017 Nov 28. PMID 28978553, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet.
      Title: CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet.
    2. CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway.
      Title: CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway.
    3. C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose-Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase.
      Title: C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose-Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase.
    4. Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress.
      Title: Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress.
    5. C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation.
      Title: C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation.
    6. Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency.
      Title: Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency.
    7. Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina.
      Title: Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina.
    8. C1q/tumour necrosis factor-related protein-9 aggravates lipopolysaccharide-induced inflammation via promoting NLRP3 inflammasome activation.
      Title: C1q/tumour necrosis factor-related protein-9 aggravates lipopolysaccharide-induced inflammation via promoting NLRP3 inflammasome activation.
    9. BCL-6 promotes the methylation of miR-34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury.
      Title: BCL-6 promotes the methylation of miR-34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury.
    10. CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux.
      Title: CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within energy homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell size IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1q and tumor necrosis factor-related protein 9
    Names
    adiponectin f1
    complement C1q tumor necrosis factor-related protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183175.4 → NP_898998.2  complement C1q and tumor necrosis factor-related protein 9 precursor

      See identical proteins and their annotated locations for NP_898998.2

      Status: VALIDATED

      Source sequence(s)
      AC151835, AW125201, DQ002401
      Consensus CDS
      CCDS27178.1
      UniProtKB/Swiss-Prot
      Q4ZJN1, Q8BZS3
      UniProtKB/TrEMBL
      A0A3B0J6Z4
      Related
      ENSMUSP00000025940.7, ENSMUST00000025940.7
      Conserved Domains (2) summary
      pfam01391
      Location:95 → 153
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:203 → 329
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      61005583..61018318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518983.3 → XP_006519046.1  complement C1q and tumor necrosis factor-related protein 9 isoform X1

      See identical proteins and their annotated locations for XP_006519046.1

      UniProtKB/Swiss-Prot
      Q4ZJN1
      Conserved Domains (2) summary
      pfam01391
      Location:2 → 58
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:65 → 191
      C1q; C1q domain

    2. XM_006518984.3 → XP_006519047.1  complement C1q and tumor necrosis factor-related protein 9 isoform X1

      See identical proteins and their annotated locations for XP_006519047.1

      UniProtKB/Swiss-Prot
      Q4ZJN1
      Conserved Domains (2) summary
      pfam01391
      Location:2 → 58
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:65 → 191
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4ZJN1.1 GenPept UniProtKB/Swiss-Prot:Q4ZJN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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