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    Igha immunoglobulin heavy constant alpha [ Mus musculus (house mouse) ]

    Gene ID: 238447, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ighaprovided by MGI
    Official Full Name
    immunoglobulin heavy constant alphaprovided by MGI
    Primary source
    MGI:MGI:96444
    See related
    Ensembl:ENSMUSG00000095079 IMGT/GENE-DB:IGHA; AllianceGenome:MGI:96444
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IgA; Igh-2
    Summary
    Enables antigen binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin and mucosal immune response. Part of immunoglobulin complex, circulating. Is expressed in large intestine and small intestine. Orthologous to human IGHA1 (immunoglobulin heavy constant alpha 1) and IGHA2 (immunoglobulin heavy constant alpha 2 (A2m marker)). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Igha in Genome Data Viewer
    Location:
    12 F1; 12 62.09 cM
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113219824..113223856, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113256204..113260236, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114425816-114425969 Neighboring gene STARR-seq mESC enhancer starr_33382 Neighboring gene STARR-positive B cell enhancer ABC_E7190 Neighboring gene STARR-positive B cell enhancer ABC_E7191 Neighboring gene STARR-positive B cell enhancer mm9_chr12:114458733-114459034 Neighboring gene STARR-positive B cell enhancer mm9_chr12:114460326-114460627 Neighboring gene STARR-positive B cell enhancer ABC_E5364 Neighboring gene STARR-positive B cell enhancer mm9_chr12:114482971-114483272 Neighboring gene transmembrane protein 121 Neighboring gene predicted gene, 25622 Neighboring gene immunoglobulin heavy constant gamma 2C Neighboring gene Immunoglobulin heavy constant epsilon Neighboring gene immunoglobulin heavy chain complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine. Lara-Padilla E, et al. J Nutr Biochem, 2011 Jun. PMID 20951020
    2. Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobulin A. O'Neal CM, et al. J Virol, 2000 May. PMID 10756022, Free PMC Article
    3. IgA immunodeficiency leads to inadequate Th cell priming and increased susceptibility to influenza virus infection. Arulanandam BP, et al. J Immunol, 2001 Jan 1. PMID 11123296
    4. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. Kihara M, et al. J Am Soc Nephrol, 2014 Jun. PMID 24511137, Free PMC Article
    5. Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. Chopra M, et al. PLoS One, 2013. PMID 24349055, Free PMC Article

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
      Title: Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
    2. In transgenic mice, IgAN pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by the Kupffer cells. Conditional IgAN progression in CD89 transgenic mice thus reveals important aspects of IgAN pathogenesis.
      Title: Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy.
    3. Increased production of IL-5 from Peyer's patch cells and the restored Th1-type immune response might cause the production of abnormal IgA and might induce the glomerular deposition of IgA in IGA nephropathy.
      Title: Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.
    4. pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
      Title: Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
    5. The differential and synergistic effect of retinoic acid and TGF-beta on switching of different B cell subpopulations to IgA, is reported.
      Title: An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-β and retinoic acid.
    6. Our data suggest a critical role of O-linked glycans attached to the hinge region in the development of IgA nephropathy-like disease induced by 6-19 IgA rheumatoid factor in mice.
      Title: O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor.
    7. Data indicate the importance of the mucosal IgA response in defense against HIV/AIDS.
      Title: Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice.
    8. Glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA.
      Title: Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.
    9. Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine
      Title: Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine.
    10. Aberrant glycosylation of immunoglobulin A causes IGA nephropathy. (review)
      Title: [Aberrant glycosylation of immunoglobulin A and renal disease].
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Other Names

    • immunoglobulin heavy chain 2 (serum IgA)

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin mediated immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mucosal immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of immunoglobulin complex, circulating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of immunoglobulin complex, circulating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of monomeric IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of secretory IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of secretory dimeric IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005838.1 

      Range
      8608..12640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113219824..113223856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024700.1: Suppressed sequence

      Description
      NM_001024700.1: This RefSeq was permanently suppressed because immunoglobulin and T-cell receptor loci are out of scope for RefSeq transcripts.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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