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    Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 234356, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Csgalnact1provided by MGI
    Official Full Name
    chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2442354
    See related
    Ensembl:ENSMUSG00000036356 AllianceGenome:MGI:2442354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CSGalNAcT-1; 4732435N03Rik
    Summary
    Enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Acts upstream of or within chondroitin sulfate metabolic process; extracellular matrix organization; and skeletal system development. Is active in Golgi apparatus. Is expressed in several structures, including alimentary system; cartilage; limb; nervous system; and sensory organ. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 2.6), frontal lobe adult (RPKM 2.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csgalnact1 in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (68809433..69188270, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68356781..68735621, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene predicted gene 15991 Neighboring gene STARR-seq mESC enhancer starr_21700 Neighboring gene predicted gene, 22018 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70681079-70681379 Neighboring gene STARR-seq mESC enhancer starr_21702 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70772052-70772353 Neighboring gene STARR-seq mESC enhancer starr_21703 Neighboring gene STARR-seq mESC enhancer starr_21704 Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene SH2 domain containing 4A Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21708 Neighboring gene STARR-seq mESC enhancer starr_21710 Neighboring gene STARR-positive B cell enhancer mm9_chr8:71151041-71151341 Neighboring gene STARR-positive B cell enhancer ABC_E5009 Neighboring gene STARR-seq mESC enhancer starr_21711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71317593-71317892 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene integrator complex subunit 10 Neighboring gene predicted gene, 51577

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type. Inada R, et al. Glycobiology, 2021 Apr 1. PMID 32839819
    2. Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis. Katagiri T, et al. Exp Hematol, 2021 Apr. PMID 33582241
    3. Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment. Yamada J, et al. J Neurosci, 2018 Sep 26. PMID 30126967, Free PMC Article
    4. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Yoshioka N, et al. Mol Brain, 2017 Oct 5. PMID 28982363, Free PMC Article
    5. Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex. Hou X, et al. Sci Rep, 2017 Oct 3. PMID 28974755, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
      Title: Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
    2. CSGalNAcT1 plays important roles in connective tissue organization and following intramembranous ossification of the craniofacial skeleton.
      Title: Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
    3. Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizing enzyme, CSGalNAcT1. Two-photon in vivo imaging showed a weaker visual response of PV-cells with reduced CS compared to wild-type mice. Plasticity onset was restored by a homeoprotein Otx2, which binds the major CS-proteoglycan aggrecan and promotes its further expression.
      Title: Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.
    4. CSGalNAcT1 is important for plasticity, probably due to regulation of chondroitin sulfate-dependent perineuronal nets.
      Title: Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.
    5. propose that both t1 and t2 are necessary for CS synthesis and normal chondrocyte differentiation but are not sufficient for all CS synthesis in cartilage
      Title: Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.
    6. CSGalNAcT-1 is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.
      Title: Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.
    7. Results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage.
      Title: Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidoglycan glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidoglycan glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylgalactosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-N-acetylgalactosamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UDP-glucuronate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-glucuronate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate N-acetylgalactosaminyltransferase 1
    Names
    beta1,4 N-acetylgalactosaminyltransferase
    beta4GalNAcT-1
    chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
    NP_001239552.1
    NP_001351185.1
    NP_766341.4
    XP_006509689.1
    XP_006509690.1
    XP_006509691.1
    XP_006509692.1
    XP_006509693.1
    XP_011240592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252623.1 → NP_001239552.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_001239552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC117740, AC123813, AC124427, AC129206, BY289912
      Consensus CDS
      CCDS22341.1
      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Related
      ENSMUSP00000119817.2, ENSMUST00000130214.8
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. NM_001364256.1 → NP_001351185.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC117740, AK049770, AK133567
      Consensus CDS
      CCDS22341.1
      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. NM_172753.5 → NP_766341.4  chondroitin sulfate N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_766341.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC117740, AK080687, BY289912
      Consensus CDS
      CCDS22341.1
      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Related
      ENSMUSP00000077459.7, ENSMUST00000078350.13
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      68809433..69188270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509628.5 → XP_006509691.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509691.1

      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_006509627.5 → XP_006509690.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509690.1

      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_011242290.4 → XP_011240592.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011240592.1

      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_006509626.3 → XP_006509689.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509689.1

      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    5. XM_006509629.2 → XP_006509692.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509692.1

      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    6. XM_006509630.5 → XP_006509693.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509693.1

      UniProtKB/Swiss-Prot
      Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
      Conserved Domains (1) summary
      cl11394
      Location:144 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RNA

    1. XR_004934803.1 RNA Sequence

    2. XR_004934802.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJQ9.1 GenPept UniProtKB/Swiss-Prot:Q8BJQ9

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