Clec2e C-type lectin domain family 2, member e [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec2eprovided by MGI
Official Full Name: C-type lectin domain family 2, member eprovided by MGI
Primary source: MGI:MGI:3028921
See related: Ensembl:ENSMUSG00000030155 AllianceGenome:MGI:3028921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clra; clr-a
Summary: Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in external side of plasma membrane. Is expressed in brain; gut; liver lobe; and retina nuclear layer. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in large intestine adult (RPKM 12.1), small intestine adult (RPKM 6.6) and 2 other tissues See more
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Genomic context

Location:: 6 F3; 6 63.13 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129068779..129077866, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129091816..129100903, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression.
Title: Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables natural killer cell lectin-like receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type lectin domain family 2 member E

Names: C-type lectin-related protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153506.4 → NP_705726.3 C-type lectin domain family 2 member E

Status: VALIDATED

Source sequence(s)

AC174446

Consensus CDS

CCDS39656.1

UniProtKB/TrEMBL

H7BWZ4, I3QI44

Related

ENSMUSP00000032258.7, ENSMUST00000032258.8

Conserved Domains (2) summary

cd03593
Location:89 → 201

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

PHA03097
Location:42 → 199

PHA03097; C-type lectin-like protein; Provisional