Ppat phosphoribosyl pyrophosphate amidotransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppatprovided by MGI
Official Full Name: phosphoribosyl pyrophosphate amidotransferaseprovided by MGI
Primary source: MGI:MGI:2387203
See related: Ensembl:ENSMUSG00000029246 AllianceGenome:MGI:2387203
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPAT; 5730454C12Rik
Summary: Enables amidophosphoribosyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Is expressed in several structures, including alimentary system; brain; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 11.6), liver E14.5 (RPKM 9.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 41.45 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (77061096..77099425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (76913249..76951578, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (1)

General gene information

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Markers

AI507113 (e-PCR)
- UniSTS:165403

RH124742 (e-PCR)
- UniSTS:161564

RH124532 (e-PCR)
- UniSTS:161354

MHAa70f1.seq (e-PCR)
- UniSTS:125290

Ppat (e-PCR), detects polymorphism
- UniSTS:546963

NoName (e-PCR)
- UniSTS:235203

RH126767 (e-PCR)
- UniSTS:207813

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables amidophosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amidophosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables amidophosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' IMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' XMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: amidophosphoribosyltransferase

Names: ATase; glutamine phosphoribosylpyrophosphate amidotransferase

NP_742158.1

EC 2.4.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172146.2 → NP_742158.1 amidophosphoribosyltransferase

See identical proteins and their annotated locations for NP_742158.1

Status: VALIDATED

Source sequence(s)

AK147750, AK148034, AK159859, AK164506, BB647933

Consensus CDS

CCDS51527.1

UniProtKB/Swiss-Prot

Q3TKC5, Q3TUW2, Q3UGU3, Q8CIH9

UniProtKB/TrEMBL

Q3UGA8

Related

ENSMUSP00000120632.2, ENSMUST00000140076.2

Conserved Domains (3) summary

cd06223
Location:306 → 442

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

COG0034
Location:8 → 515

PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]

cd00715
Location:12 → 295

GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...