Dyrk3 dual-specificity tyrosine phosphorylation regulated kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dyrk3provided by MGI
Official Full Name: dual-specificity tyrosine phosphorylation regulated kinase 3provided by MGI
Primary source: MGI:MGI:1330300
See related: Ensembl:ENSMUSG00000016526 AllianceGenome:MGI:1330300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including erythrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; and protein phosphorylation. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; musculature; and nasal cavity epithelium. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 67.2), liver E14.5 (RPKM 10.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131056178..131065991, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131128441..131138234, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DYRK3 contributes to differentiation and hypoxic control in neuroblastoma.
Title: DYRK3 contributes to differentiation and hypoxic control in neuroblastoma.
Study identified the dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) as a protein with the ability to condense P-granule-like speckles in the cytosol and to prevent stress granule dissolution via its N-terminal domain when it is in a kinase-inactive form.
Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia
Title: DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.
DYRK3, expression is strong in erythroid cells and testis, but is also detected in adult kidney and liver
Title: DYRK gene structure and erythroid-restricted features of DYRK3 gene expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dyrk3 (e-PCR), detects polymorphism
- UniSTS:530947

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear speck organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear speck organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle disassembly	ISO Inferred from Sequence Orthology more info
involved_in organelle disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell cycle G2/M phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G2/M phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress granule disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress granule disassembly	ISO Inferred from Sequence Orthology more info
involved_in stress granule disassembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 3

Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

NP_001404999.1

EC 2.7.12.1

NP_001405000.1

EC 2.7.12.1

NP_001405001.1

EC 2.7.12.1

NP_001405002.1

EC 2.7.12.1

NP_001405003.1

EC 2.7.12.1

NP_001405004.1

EC 2.7.12.1

NP_663483.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418070.1 → NP_001404999.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

Status: VALIDATED

Source sequence(s)

AL513351
NM_001418071.1 → NP_001405000.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

Status: VALIDATED

Source sequence(s)

AL513351
NM_001418072.1 → NP_001405001.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

Status: VALIDATED

Source sequence(s)

AL513351
NM_001418073.1 → NP_001405002.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

Status: VALIDATED

Source sequence(s)

AL513351
NM_001418074.1 → NP_001405003.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

Status: VALIDATED

Source sequence(s)

AL513351
NM_001418075.1 → NP_001405004.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

Status: VALIDATED

Source sequence(s)

AL513351
NM_145508.3 → NP_663483.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

See identical proteins and their annotated locations for NP_663483.1

Status: VALIDATED

Source sequence(s)

AL513351

Consensus CDS

CCDS15267.1

UniProtKB/Swiss-Prot

Q8BM34, Q922Y0

Related

ENSMUSP00000016670.8, ENSMUST00000016670.9

Conserved Domains (2) summary

smart00220
Location:208 → 521

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:142 → 521

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3