Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ywhaqprovided by MGI
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaprovided by MGI
Primary source: MGI:MGI:891963
See related: Ensembl:ENSMUSG00000076432 AllianceGenome:MGI:891963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700028P07Rik
Summary: Enables protein domain specific binding activity. Acts upstream of or within protein targeting and small GTPase-mediated signal transduction. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 170.8), CNS E14 (RPKM 138.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.3; 12 8.31 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (21440330..21467437, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (21390329..21417436, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting 14-3-3theta;-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.
Title: Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.
Title: 14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.
Rod photoreceptors are enriched in YWHAE (14-3-3 epsilon). Immunohistochemistry revealed that 14-3-3 epsilon and 14-3-3 zeta exhibit unique distributions in photoreceptors with 14-3-3 epsilon restricted to the inner segment and 14-3-3 zeta localized to the outer segment.
Title: Analysis of 14-3-3 isoforms expressed in photoreceptors.
analysis of phosphorylation-dependent interactions of AQP2 with 14-3-3theta; and -zeta
Title: Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ.
Results identify a critical role for 14-3-3tau in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIalpha, a negative regulator of Rho GTPases and a metastasis suppressor. [14-3-3tau]
Title: 14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.
Data show that IkappaB kinase (IKK) phosphorylation of the TPL-2 kinase (TPL-2) induces 14-3-3 association with TPL-2, stimulating its MEK kinase activity, which is essential for TPL-2 activation of ERK-1/2.
Title: IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
There is a scaffolding role for 14-3-3theta in assisting the delivery of Cx43 and integrin alpha5 to the plasma membrane for the formation of mechanosensitive hemichannels in osteocytes.
Title: 14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels.
14-3-3 negatively regulates the RGC downstream of the PI3-kinase/Akt signaling pathway
Title: Negative regulation of the RalGAP complex by 14-3-3.
14-3-3 theta is a new and important regulatory protein in the TLR-2 and TLR-4 signaling suppressing the MyD88-dependent pathway
Title: Identification and functional characterization of 14-3-3 in TLR2 signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136453 (e-PCR)
- UniSTS:210439

Ywhaq (e-PCR), detects polymorphism
- UniSTS:526907

RH125095 (e-PCR)
- UniSTS:161917

RH126547 (e-PCR)
- UniSTS:208786

Ywhaq (e-PCR), detects polymorphism
- UniSTS:144815

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 14-3-3 protein theta

Names: 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 tau; 14-3-3 theta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.