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    Wee1 WEE 1 homolog 1 (S. pombe) [ Mus musculus (house mouse) ]

    Gene ID: 22390, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wee1provided by MGI
    Official Full Name
    WEE 1 homolog 1 (S. pombe)provided by MGI
    Primary source
    MGI:MGI:103075
    See related
    Ensembl:ENSMUSG00000031016 AllianceGenome:MGI:103075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wee1A
    Summary
    Enables protein kinase activity. Acts upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Located in cytoplasm. Is expressed in several structures, including brain ventricular layer; early embryo; gut; humerus; and inferior colliculus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.3), placenta adult (RPKM 11.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wee1 in Genome Data Viewer
    Location:
    7 E3; 7 57.7 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109721266..109742506)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110122059..110143299)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene zinc finger protein 143 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene STARR-positive B cell enhancer ABC_E8201 Neighboring gene predicted gene, 51505 Neighboring gene STARR-positive B cell enhancer ABC_E704 Neighboring gene SWA-70 protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases. Chen ZL, et al. Signal Transduct Target Ther, 2024 Jul 12. PMID 38992067, Free PMC Article
    2. Autophagy modulates the stability of Wee1 and cell cycle G2/M transition. Han B, et al. Biochem Biophys Res Commun, 2023 Oct 15. PMID 37549603, Free PMC Article
    3. Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Tominaga Y, et al. Int J Biol Sci, 2006. PMID 16810330, Free PMC Article
    4. Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells. Hong KS, et al. Exp Mol Med, 2011 Dec 31. PMID 21918363, Free PMC Article
    5. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Guo E, et al. J Exp Med, 2022 Jan 3. PMID 34825915, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng.
      Title: Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng.
    2. Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
      Title: Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
    3. Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases.
      Title: Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases.
    4. Autophagy modulates the stability of Wee1 and cell cycle G2/M transition.
      Title: Autophagy modulates the stability of Wee1 and cell cycle G2/M transition.
    5. Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-gammaH2AX-MDC1.
      Title: Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1.
    6. WEE1 promotes endometriosis via the Wnt/beta-catenin signaling pathway.
      Title: WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway.
    7. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
      Title: WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
    8. Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting the morphine-induced macrophage apoptosis.
      Title: MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.
    9. Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor.
      Title: WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
    10. Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage.
      Title: Involvement of Wee1 in the circadian rhythm-dependent intestinal damage induced by docetaxel.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    wee1-like protein kinase
    Names
    WEE1 tyrosine kinase
    wee1A kinase
    NP_001341987.1
    NP_033542.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355058.1 → NP_001341987.1  wee1-like protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC147244
      Conserved Domains (1) summary
      cl21453
      Location:292 → 518
      PKc_like; Protein Kinases, catalytic domain

    2. NM_009516.3 → NP_033542.2  wee1-like protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033542.2

      Status: VALIDATED

      Source sequence(s)
      AK011212, AK039572, BY631896, CJ130595
      Consensus CDS
      CCDS21743.1
      UniProtKB/Swiss-Prot
      P47810, Q9EPL7
      Related
      ENSMUSP00000033326.9, ENSMUST00000033326.10
      Conserved Domains (2) summary
      cd14138
      Location:292 → 567
      PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a
      pfam00069
      Location:298 → 568
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109721266..109742506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47810.2 GenPept UniProtKB/Swiss-Prot:P47810

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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