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    Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 22163, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tnfrsf4provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 4provided by MGI
    Primary source
    MGI:MGI:104512
    See related
    Ensembl:ENSMUSG00000029075 AllianceGenome:MGI:104512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
    Summary
    Enables tumor necrosis factor receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; negative regulation of cytokine production; and regulation of protein kinase activity. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 16. Orthologous to human TNFRSF4 (TNF receptor superfamily member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 42.7), genital fat pad adult (RPKM 36.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfrsf4 in Genome Data Viewer
    Location:
    4 E2; 4 87.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156098049..156101070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156013595..156016613)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related 12 Neighboring gene predicted gene, 42365 Neighboring gene STARR-seq mESC enhancer starr_12278 Neighboring gene STARR-seq mESC enhancer starr_12279 Neighboring gene UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 Neighboring gene stromal cell derived factor 4 Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982 Neighboring gene tumor necrosis factor receptor superfamily, member 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Kim MY, et al. Immunity, 2003 May. PMID 12753741
    2. OX40 (CD134) blockade inhibits the co-stimulatory cascade and promotes heart allograft survival. Curry AJ, et al. Transplantation, 2004 Sep 27. PMID 15385798
    3. Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Redmond WL, et al. Eur J Immunol, 2009 Aug. PMID 19672905, Free PMC Article
    4. Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells. Sun G, et al. Cell Death Dis, 2018 May 23. PMID 29795285, Free PMC Article
    5. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy. Bulliard Y, et al. Immunol Cell Biol, 2014 Jul. PMID 24732076

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity.
      Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
    2. T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
      Title: T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
    3. TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
      Title: TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
    4. OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
      Title: OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
    5. OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
      Title: OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
    6. Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
      Title: Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
    7. Critical role of OX40 in drug-induced acute liver injury.
      Title: Critical role of OX40 in drug-induced acute liver injury.
    8. Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
      Title: Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
    9. OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.
      Title: OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.
    10. Pulmonary group 2 innate lymphoid cells may regulate RSV-induced CD4+T cell expansion and activation via OX40/OX40L interaction. Our results might provide a novel understanding of the underlying mechanisms of respiratory tract diseases mediated by type 2 immunity and be useful to improve the insights and therapies for RSV-induced or RSV-aggravated asthma.
      Title: Critical role of OX40/OX40L in ILC2-mediated activation of CD4(+)T cells during respiratory syncytial virus infection in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (110)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (10) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of activation-induced cell death of T cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cytokine production IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of immunoglobulin production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 4
    Names
    OX40 antigen
    OX40L receptor
    tax-transcriptionally activated glycoprotein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011659.2 → NP_035789.1  tumor necrosis factor receptor superfamily member 4 precursor

      See identical proteins and their annotated locations for NP_035789.1

      Status: PROVISIONAL

      Source sequence(s)
      AL627204
      Consensus CDS
      CCDS19055.1
      UniProtKB/Swiss-Prot
      P47741
      UniProtKB/TrEMBL
      B1ASL3
      Related
      ENSMUSP00000030952.6, ENSMUST00000030952.6
      Conserved Domains (1) summary
      cd13406
      Location:25 → 168
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156098049..156101070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538724.4 → XP_006538787.3  tumor necrosis factor receptor superfamily member 4 isoform X1

      Conserved Domains (1) summary
      cd13406
      Location:113 → 256
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47741.1 GenPept UniProtKB/Swiss-Prot:P47741

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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