Ghsr growth hormone secretagogue receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ghsrprovided by MGI
Official Full Name: growth hormone secretagogue receptorprovided by MGI
Primary source: MGI:MGI:2441906
See related: Ensembl:ENSMUSG00000051136 AllianceGenome:MGI:2441906
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GHRP; GHS-R; Ghsr1a; C530020I22Rik
Summary: Predicted to enable G protein-coupled receptor activity; identical protein binding activity; and peptide hormone binding activity. Involved in adult feeding behavior and positive regulation of appetite. Acts upstream of or within several processes, including cellular response to insulin stimulus; growth hormone secretion; and positive regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cell surface; membrane raft; and neuron projection. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and trachea. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 10.86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (27425500..27433384)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (27371351..27379235)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner.
Title: The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner.
Increased GHS-R1a expression in the hippocampus impairs memory encoding and contributes to AD-associated memory deficits.
Title: Increased GHS-R1a expression in the hippocampus impairs memory encoding and contributes to AD-associated memory deficits.
GHS-R1a deficiency protects against lipopolysaccharide-induced spatial memory impairment in mice.
Title: GHS-R1a deficiency protects against lipopolysaccharide-induced spatial memory impairment in mice.
Growth Hormone Secretagogue Receptor (GHSR) Signaling in the Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic Social Defeat Stress in Male Mice.
Title: Growth Hormone Secretagogue Receptor (GHSR) Signaling in the Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic Social Defeat Stress in Male Mice.
GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice.
Title: GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice.
Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation.
Title: Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation.
Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation.
Title: Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation.
Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-beta Knockin Mice During Aging.
Title: Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging.
Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice.
Title: Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice.
GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement.
Title: GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (12) 1 citation

General gene information

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Markers

33.MMHAP61FRC12.seq (e-PCR)
- UniSTS:124043

NoName (e-PCR)
- UniSTS:495010

NoName (e-PCR)
- UniSTS:490706

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth hormone secretagogue receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone secretagogue receptor activity	ISO Inferred from Sequence Orthology more info
enables growth hormone secretagogue receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth hormone-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables growth hormone-releasing hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin-like growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to thyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in decidualization	ISS Inferred from Sequence or Structural Similarity more info
involved_in ghrelin secretion	IEA Inferred from Electronic Annotation more info
involved_in ghrelin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within growth hormone secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of eating behavior	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of small intestinal transit	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of small intestinal transit	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small intestine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of small intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastric motility	IEA Inferred from Electronic Annotation more info
involved_in regulation of gastric motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of hindgut contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of hindgut contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
involved_in regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to follicle-stimulating hormone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to food	IDA Inferred from Direct Assay more info	PubMed
involved_in response to growth hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth hormone secretagogue receptor type 1

Names: G-protein coupled receptor; GH-releasing peptide receptor; ghrelin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177330.4 → NP_796304.1 growth hormone secretagogue receptor type 1

See identical proteins and their annotated locations for NP_796304.1

Status: VALIDATED

Source sequence(s)

AC116585

Consensus CDS

CCDS17273.1

UniProtKB/Swiss-Prot

Q8BWX8, Q91Z82, Q99P50

UniProtKB/TrEMBL

Q0VBE5

Related

ENSMUSP00000061153.2, ENSMUST00000057186.2

Conserved Domains (1) summary

cd15131
Location:44 → 332

7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

27425500..27433384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319513.2 → XP_017175002.1 growth hormone secretagogue receptor type 1 isoform X1

Conserved Domains (1) summary

cd15131
Location:107 → 395

7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors