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    Yeats2 YEATS domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 208146, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Yeats2provided by MGI
    Official Full Name
    YEATS domain containing 2provided by MGI
    Primary source
    MGI:MGI:2447762
    See related
    Ensembl:ENSMUSG00000041215 AllianceGenome:MGI:2447762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1197
    Summary
    Predicted to enable several functions, including TBP-class protein binding activity; histone reader activity; and transcription corepressor activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in mitotic spindle and nucleus. Part of ATAC complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 38.3), CNS E14 (RPKM 32.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Yeats2 in Genome Data Viewer
    Location:
    16 A3; 16 12.37 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19959803..20051323)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20141053..20232573)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene kelch-like 6 Neighboring gene STARR-seq mESC enhancer starr_40309 Neighboring gene STARR-positive B cell enhancer ABC_E2456 Neighboring gene STARR-positive B cell enhancer ABC_E1183 Neighboring gene kelch-like 24 Neighboring gene STARR-seq mESC enhancer starr_40314 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40316 Neighboring gene predicted gene, 41431 Neighboring gene MAP6 domain containing 1 Neighboring gene predicted gene, 49566

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth. Wu Q, et al. Cell Cycle, 2024 Feb. PMID 38619971,
    2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    3. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620, Free PMC Article
    4. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
    5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
      Title: Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone reader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    YEATS domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033237.2 → NP_001028409.2  YEATS domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an exon found in transcript variant 1, which results in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK160791, BC150944, BU055428, CB182287
      Consensus CDS
      CCDS28043.1
      UniProtKB/TrEMBL
      B9EKJ4
      Related
      ENSMUSP00000087506.5, ENSMUST00000090052.11
      Conserved Domains (2) summary
      PRK07003
      Location:834 → 1070
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:156 → 279
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    2. NM_001145930.1 → NP_001139402.1  YEATS domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001139402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK160791, AK165933, BC150944, BU055428, CB182287
      Consensus CDS
      CCDS49790.1
      UniProtKB/Swiss-Prot
      Q3TUF7, Q6PGF8, Q80TI2, Q8CG86
      UniProtKB/TrEMBL
      A0A338P697
      Related
      ENSMUSP00000111222.3, ENSMUST00000115560.4
      Conserved Domains (2) summary
      PRK07003
      Location:887 → 1123
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:209 → 332
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    3. NM_001145931.1 → NP_001139403.1  YEATS domain-containing protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate segment at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA138143, AC120150, AK165933, BU055428
      Conserved Domains (1) summary
      pfam03366
      Location:232 → 309
      YEATS; YEATS family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      19959803..20051323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521903.4 → XP_006521966.1  YEATS domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A338P697
      Conserved Domains (2) summary
      PRK07003
      Location:884 → 1120
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:206 → 329
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    2. XM_036159831.1 → XP_036015724.1  YEATS domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A338P697
      Conserved Domains (2) summary
      PRK07003
      Location:884 → 1120
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:206 → 329
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    3. XM_006521904.3 → XP_006521967.1  YEATS domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A338P697
      Conserved Domains (2) summary
      PRK07003
      Location:887 → 1123
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:209 → 332
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    4. XM_006521905.3 → XP_006521968.1  YEATS domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A338P697
      Conserved Domains (2) summary
      PRK07003
      Location:790 → 1026
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:209 → 332
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    5. XM_030249018.1 → XP_030104878.1  YEATS domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      B9EKJ4
      Related
      ENSMUSP00000155892.2, ENSMUST00000232019.2
      Conserved Domains (2) summary
      PRK07003
      Location:831 → 1067
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:153 → 276
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    6. XM_006521902.5 → XP_006521965.1  YEATS domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521965.1

      UniProtKB/Swiss-Prot
      Q3TUF7, Q6PGF8, Q80TI2, Q8CG86
      UniProtKB/TrEMBL
      A0A338P697
      Conserved Domains (2) summary
      PRK07003
      Location:887 → 1123
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:209 → 332
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    7. XM_030249017.1 → XP_030104877.1  YEATS domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A338P697
      Conserved Domains (2) summary
      PRK07003
      Location:884 → 1120
      PRK07003; DNA polymerase III subunit gamma/tau
      cd16907
      Location:206 → 329
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    8. XM_036159832.1 → XP_036015725.1  YEATS domain-containing protein 2 isoform X8

      Conserved Domains (1) summary
      PRK07003
      Location:432 → 668
      PRK07003; DNA polymerase III subunit gamma/tau

    9. XM_006521906.5 → XP_006521969.1  YEATS domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      B9EKJ4
      Conserved Domains (1) summary
      PRK07003
      Location:619 → 855
      PRK07003; DNA polymerase III subunit gamma/tau

    RNA

    1. XR_001781806.3 RNA Sequence

    2. XR_384540.4 RNA Sequence

      Related
      ENSMUST00000232338.2

    3. XR_384538.4 RNA Sequence

    4. XR_004939174.1 RNA Sequence

    5. XR_001781807.2 RNA Sequence

    6. XR_384537.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TUF7.2 GenPept UniProtKB/Swiss-Prot:Q3TUF7

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