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    Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 20663, updated on 28-Oct-2024

    Summary

    Official Symbol
    Sos2provided by MGI
    Official Full Name
    SOS Ras/Rho guanine nucleotide exchange factor 2provided by MGI
    Primary source
    MGI:MGI:98355
    See related
    Ensembl:ENSMUSG00000034801 AllianceGenome:MGI:98355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SOS-2; mSOS-2
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in insulin receptor signaling pathway. Acts upstream of or within several processes, including B cell homeostasis; regulation of T cell activation; and regulation of pro-B cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.8), CNS E18 (RPKM 5.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sos2 in Genome Data Viewer
    Location:
    12 C2; 12 28.93 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69630535..69728626, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69583761..69681852, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46353 Neighboring gene STARR-positive B cell enhancer ABC_E7141 Neighboring gene valosin containing protein lysine (K) methyltransferase Neighboring gene STARR-seq mESC enhancer starr_32372 Neighboring gene predicted gene, 24449 Neighboring gene predicted gene, 31679 Neighboring gene STARR-positive B cell enhancer ABC_E10756 Neighboring gene STARR-seq mESC enhancer starr_32373 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_32374 Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene distal membrane arm assembly component 2 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135559.1NP_001129031.1  son of sevenless homolog 2

      Status: VALIDATED

      Source sequence(s)
      AC133949, AC141560, AC153658
      Consensus CDS
      CCDS59573.1
      UniProtKB/TrEMBL
      A0A0A0MQ87, S4R2C4
      Related
      ENSMUSP00000044866.8, ENSMUST00000035773.14
      Conserved Domains (7) summary
      smart00147
      Location:7741018
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:595739
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00160
      Location:200386
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:437543
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:63169
      Histone; Core histone H2A/H2B/H3/H4
      pfam00169
      Location:443544
      PH; PH domain
      cl23907
      Location:97147
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69630535..69728626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515635.2XP_006515698.1  son of sevenless homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006515698.1

      UniProtKB/Swiss-Prot
      Q02384
      UniProtKB/TrEMBL
      S4R2C4
      Related
      ENSMUSP00000138793.2, ENSMUST00000183277.8
      Conserved Domains (5) summary
      smart00147
      Location:7751019
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:596740
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00160
      Location:200387
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:438544
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:70169
      Histone; Core histone H2A/H2B/H3/H4