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    Rad52 RAD52 homolog, DNA repair protein [ Mus musculus (house mouse) ]

    Gene ID: 19365, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rad52provided by MGI
    Official Full Name
    RAD52 homolog, DNA repair proteinprovided by MGI
    Primary source
    MGI:MGI:101949
    See related
    Ensembl:ENSMUSG00000030166 AllianceGenome:MGI:101949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rad52yh
    Summary
    Predicted to enable identical protein binding activity and single-stranded DNA binding activity. Involved in DNA double-strand break processing involved in repair via single-strand annealing. Acts upstream of or within cellular response to oxidative stress and double-strand break repair via homologous recombination. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung cancer (multiple); mucoepidermoid carcinoma; and nicotine dependence. Orthologous to human RAD52 (RAD52 homolog, DNA repair protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.7), limb E14.5 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rad52 in Genome Data Viewer
    Location:
    6 F1; 6 56.86 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119878781..119899789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119901722..119922827)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene STARR-seq mESC enhancer starr_17154 Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_17155 Neighboring gene STARR-seq mESC enhancer starr_17156 Neighboring gene STARR-positive B cell enhancer mm9_chr6:119988697-119988998 Neighboring gene STARR-positive B cell enhancer ABC_E1708 Neighboring gene STARR-positive B cell enhancer ABC_E8832 Neighboring gene STARR-positive B cell enhancer ABC_E11333 Neighboring gene microRNA 706 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120061967-120062268 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120062467-120062768 Neighboring gene STARR-seq mESC enhancer starr_17160 Neighboring gene ninjurin 2 Neighboring gene predicted gene, 25327

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of small polyadenylated B2 RNA. Kramerov DA, et al. Nucleic Acids Res, 1985 Sep 25. PMID 2414725, Free PMC Article
    2. Genetic control of intrachromosomal recombination. Klein HL. Bioessays, 1995 Feb. PMID 7748165
    3. Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52. Bendixen C, et al. Genomics, 1994 Sep 1. PMID 7829098
    4. Genomic characterization of the mouse homolog of the Saccharomyces cerevisiae recombination and double-strand break repair gene RAD52. van den Ouweland J, et al. Mutat Res, 1997 Mar 12. PMID 9088345
    5. Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Rijkers T, et al. Mol Cell Biol, 1998 Nov. PMID 9774658, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rad52 mediates class-switch DNA recombination to IgD.
      Title: Rad52 mediates class-switch DNA recombination to IgD.
    2. RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3alpha Co-localization.
      Title: RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization.
    3. Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes.
      Title: The concerted roles of FANCM and Rad52 in the protection of common fragile sites.
    4. Rad52 competes with Ku for binding to S-region double-strand DNA breaks (DSB) free ends, where it facilitates a DSB synaptic process, which favours intra-S region recombination.
      Title: Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.
    5. Results demonstrate that Rad52 depletion increased cell death, decreased myeloid cell frequency, and augmented the activity of CD8+ T cells and NK effectors that ultimately led to reduced tumor growth. These data provide support for the notion of RAD52 as a potential oncogene, implicating a major role for the combined processes of recombinational repair and host immunity in determining risk for Squamous Cell.
      Title: Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance.
    6. In cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
      Title: Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.
    7. Rad54 has a key function in maintaining genomic integrity of the developing germ cells.
      Title: Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress.
    8. Results indicate that RAD52 cooperates with OGG1 to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
      Title: The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells.
    9. RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
      Title: Suppression of retroviral infection by the RAD52 DNA repair protein.
    10. Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.
      Title: Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in DNA double-strand break processing involved in repair via single-strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA double-strand break processing involved in repair via single-strand annealing ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in DNA recombinase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via single-strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA repair protein RAD52 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166381.2 → NP_001159853.1  DNA repair protein RAD52 homolog isoform 1

      See identical proteins and their annotated locations for NP_001159853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC117667
      Consensus CDS
      CCDS51887.1
      UniProtKB/Swiss-Prot
      P43352
      Related
      ENSMUSP00000125502.2, ENSMUST00000162461.7
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    2. NM_001166382.2 → NP_001159854.1  DNA repair protein RAD52 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC117667
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    3. NM_001410284.1 → NP_001397213.1  DNA repair protein RAD52 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117667

    4. NM_001410285.1 → NP_001397214.1  DNA repair protein RAD52 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC117667

    5. NM_001410286.1 → NP_001397215.1  DNA repair protein RAD52 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117667

    6. NM_001410287.1 → NP_001397216.1  DNA repair protein RAD52 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC117667

    7. NM_001410288.1 → NP_001397217.1  DNA repair protein RAD52 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117667

    8. NM_001410289.1 → NP_001397218.1  DNA repair protein RAD52 homolog isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC117667

    9. NM_001410290.1 → NP_001397219.1  DNA repair protein RAD52 homolog isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC117667

    10. NM_011236.3 → NP_035366.2  DNA repair protein RAD52 homolog isoform 4

      See identical proteins and their annotated locations for NP_035366.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC117667
      Consensus CDS
      CCDS20477.1
      UniProtKB/TrEMBL
      G5E879
      Related
      ENSMUSP00000032269.7, ENSMUST00000032269.12
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    RNA

    1. NR_149727.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1.This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC117667
      Related
      ENSMUST00000161045.8

    2. NR_176974.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117667

    3. NR_176975.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117667

    4. NR_176977.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117667

    5. NR_176978.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117667

    6. NR_176979.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117667

    7. NR_176980.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117667

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119878781..119899789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505764.5 → XP_006505827.1  DNA repair protein RAD52 homolog isoform X1

      See identical proteins and their annotated locations for XP_006505827.1

      UniProtKB/TrEMBL
      Q8VEE2
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    2. XM_006505765.5 → XP_006505828.1  DNA repair protein RAD52 homolog isoform X4

      Conserved Domains (1) summary
      cl01936
      Location:1 → 144
      Rad52_Rad22; Rad52/22 family double-strand break repair protein

    3. XM_011241256.4 → XP_011239558.1  DNA repair protein RAD52 homolog isoform X2

      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    4. XM_006505766.5 → XP_006505829.1  DNA repair protein RAD52 homolog isoform X5

      Conserved Domains (1) summary
      cl01936
      Location:39 → 117
      Rad52_Rad22; Rad52/22 family double-strand break repair protein

    5. XM_036165959.1 → XP_036021852.1  DNA repair protein RAD52 homolog isoform X4

      Conserved Domains (1) summary
      cl01936
      Location:1 → 144
      Rad52_Rad22; Rad52/22 family double-strand break repair protein

    RNA

    1. XR_001785110.2 RNA Sequence

    2. XR_001785111.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001166383.1: Suppressed sequence

      Description
      NM_001166383.1: This RefSeq was removed because currently there is insufficient support for the 3'' end of the transcript and the C-terminus of the protein.

    2. NR_176976.1: Suppressed sequence

      Description
      NR_176976.1: This RefSeq was removed because of redundancy with NR_176975.1.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43352.1 GenPept UniProtKB/Swiss-Prot:P43352

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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